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Speaking of ingredient list, why would a manufacturer include hemp seed oil and hemp oil as separate entities when the HIA already clarified that hemp oil is hemp seed oil and vice versa? This can only support the notion that what manufacturers refer to as hemp oil is actually CBD oil. That is why they also listed hemp seed oil in their ingredient list. Another concern that we have encountered is the relationship between cannabidiol and tetrahydrocannabinol, the active ingredient in marijuana that is more known for its psychoactive effects.
The good news is that cannabidiol has been proven to lack the psychoactive effects of THC. While both molecules actually come from cannabigerolic acid, the main difference is in the enzyme that acts on this precursor molecule.
The difference in enzyme systems is what differentiates the cannabinoid that causes addiction from the cannabinoid that provides a variety of health benefits. Tetrahydrocannabinol or THC is one of the most-studied cannabinoid on the planet. On the other hand, not much is known about cannabidiol or CBD.
So how does CBD for dogs work? To understand this it is important to understand a few things. These receptors are labeled as CB1 and CB2 by scientists. Cannabinoid type 1 CB1 receptors are mostly found in the nervous system, both central and peripheral. When these receptors are stimulated they cause a reduction in intracellular cAMP by inhibiting the production of adenylate cyclase. In other words, CB1 receptors induce a reduction in nerve impulse transmission since cAMP is a nervous system messenger.
Cannabinoid type 2 CB2 receptors are mostly found in the immune system, the gastrointestinal system, and the peripheral nervous system; although recent studies say that CB2 receptors are also found in the brain, albeit in substantially lesser amounts than CB1 receptors. In the immune system, these receptors have been isolated in the thymus, tonsils, and spleen where they are observed to be responsible for the release of cytokines.
Cannabinoid type 2 receptors are mostly found in macrophages, T-lymphocytes, B-lymphocytes, and monocytes of the immune system. Specifically, these receptors help prevent the inactivation of the normal gut flora. Cannabinoid type 2 receptors are also known to play a role in alleviating pain originating from peripheral tissues, although not coming from nociceptive neurons. Why is it important to learn the two cannabinoid receptors?
Well, as we have already mentioned, cannabidiol or CBD exerts its effects primarily by interacting with these receptors. As such, you can say that learning the activities of these receptors can also pave the way towards greater understanding of the action of CBD. But, there is a catch. It also interacts with both CB1 and CB2. It is the last statement that we will look into the second most important element to understanding how cannabidiol or CBD works.
It is also for this reason that these naturally-occurring cannabinoids make up what is now known as the endocannabinoid system or ECS. Here is a list of the different functions that the endocannabinoid system is known for. Cannabidiol CBD does not only exert its effects on the endocannabinoid system. It also acts on the serotonin receptor known as 5-HT 1A.
This receptor also plays a role in inhibitory neurotransmission. CBD has been known to exhibit an agonistic activity to this serotonin receptor which can help further explain its use in both seizure and anxiety control in dogs. This action on the receptor is also what gives CBD its neuroprotective properties. The mechanisms of action that we have discussed in the preceding section are what give cannabidiol CBD oil its exceptional properties in the management of a variety of health conditions in dogs.
Here is a list of the medical conditions that CBD for dogs can help with. The double action of CBD acting on the inhibitory neurotransmission mechanism of the endocannabinoids as well as the natural inhibitory effect of serotonin receptors help provide for a calmer and less anxious dog.
We already know that the principal effect of cannabinoids in the central nervous system is the tempering of excitatory impulses, generally by inhibiting the release of cyclic-AMP. What this means is that nerve impulses are not sent from one neuron to another. This causes a generalized reduction in brain electrical activity. In short, the brain is able to go into a more relaxed and calmer state, something that you would want to happen in an anxious dog.
Many of these medications act by stimulating serotonin receptors which, in turn, increases the amount of the inhibitory neurotransmitter in the brain. While one of the effects of serotonin is an elevation of mood, it also has a more pronounced effect on reducing symptoms of anxiety or even fear.
Given that dogs also experience fear or anxiety and that this can be demonstrated in a variety of dog behaviors such as accidents, howling, barking, aggression , chewing , and even muscle tremors, providing them with CBD oil should help ensure a calmer, more peaceful dog. One of the most sought-after effects of CBD oil is the management of seizures and seizure-like manifestations such as muscle spasms, tremors, and even tics.
Seizures or convulsions are typically described as involuntary and uncontrollable contractions of the muscles. These are brought about by the abnormally erratic firing of electrical nerve impulses originating from the brain. Instead of synchronized discharge of nerve impulses, what happens is that there is asynchronicity.
Neurotransmitters are sent out from one neuron to the next, typically in rapid succession but more importantly in a disorganized manner. Since the skeletal muscles are innervated by the peripheral nervous system, they receive these asynchronous, erratic neural messages such that they contract in an uncontrollable fashion. Furthermore, because of the flooding of electrical nerve impulses at the motor endplates of muscles, the contractions are sustained and more forceful than ever.
The problem here is not really in the muscle itself, but rather in the brain. If the seizure takes an unusually long time to subside, there is a possibility that the area upon which these abnormal neuronal discharges occur will be greatly deprived of glucose and oxygen. This can lead to substantial reduction in brain tissue oxygenation, a condition medical and veterinary professionals call cerebral hypoxia.
Cerebral hypoxia, if not treated immediately, can lead to irreversible death to the cells of that part of the brain. Stroke may ensue or, in most cases, cerebral hypoperfusion injuries can occur. These can send your dog into a coma if not death. Cannabidiol can help reduce the severity of convulsions or seizures by preventing the likelihood of hyper-excitable neurons. This helps prevent the abnormal erratic discharges from the brain itself.
There are many theories about pain. However, when it comes to the use of cannabinoids in the management of pain, it is a widely-held observation that its analgesic effects are closely related to the modulation of noradrenaline coming from the brainstem and descending towards the dorsal horn of the spinal cord.
What happens is that these nerve fibers are known to possess GABAergic activity or one that is fully capable of suppressing nerve excitation. When endocannabinoids such as palmitoylethanolamide and anandemide bind to certain receptors in the descending tract of the spinal column, they increase the release of noradrenaline which help attenuate the pain impulses being processed by the noxious sensory neurons found in the dorsal horn. In other words, they block the processing of these pain impulses by flooding it with noradrenaline while also increasing the inhibitory properties of GABAergic fibers.
This can have significant implications in the management of pain in dogs. We mentioned above that cannabidiol has excellent anti-inflammatory effect. This was highlighted in a research that showed CBD to be especially effective in reducing the symptoms of inflammation in acute lung injury.
Another study on the same year also established the crucial anti-inflammatory activities of CBD in the management of acute pancreatitis. These 2 studies supported the earlier investigation that suggested CBD as an important adjunct in the management of neuropathic pain and chronic inflammation. While it is easy to say that these studies were never performed using dogs as test subjects, using laboratory mice instead, the results nevertheless, underscore the increasing importance of cannabidiol in the management of chronic inflammatory disorders.
The ability of cannabidiol as a powerful anti-inflammatory is strongly associated with the location of the cannabinoid type 2 CB2 receptors which are mostly found in immune system cells such as monocytes, macrophages, and T- and B- lymphocytes.
Its activity on cytokines help improve the anti-inflammatory action of these immune system cells so that they become very efficient in the management of chronic inflammatory disorders in dogs such as arthritis , inflammatory bowel disorder, canine encephalitis, canine chronic bronchitis, masticatory muscle myositis, acquired myasthenia gravis, and even demodectic mange. Since one of the cardinal signs of inflammatory processes is the occurrence of pain, the action of cannabidiol on immune system cells can help target two principal problems: There are a lot of reasons why dogs can get nausea or exhibit vomiting.
However, it can also be brought about by other reasons such as bacterial infections, foreign body ingestion, acute liver failure, intestinal parasitism, pancreatitis, viral infections, inflammation of the gallbladder, and even as effects of undergoing surgery. Whatever the case, nausea and vomiting in dogs are almost always characterized by abnormal gastric and intestinal motility.
There are three ways in which cannabidiol can help dogs with nausea and vomiting. First, by interacting with CB1 receptors, the endogenous cannabinoids released will help inhibit the firing of cAMP into succeeding neurons.
This helps reduce the number of electrical impulses traveling towards the gut, reducing gastric and intestinal motility. Second, since CB2 receptors are also abundant in the gastrointestinal system, their stimulation can help prevent the activity of the immune system on normal gut flora, allowing for the more efficient digestion and absorption of food molecules which can help minimize nausea and vomiting. Stimulation of the serotonin receptor has been proven to reduce the sensation of nausea while also suppressing the vomiting reflex.
One of the most remarkable areas where cannabidiol preparations are now being used on dogs is in the management of certain types of cancers. The area has received widespread attention when several promising studies showed the potentially beneficial effects of CBD on cancer treatment. For example, the Boston-based Beth Israel Deaconess Medical Center showed in that cannabidiol has the potential to cause apoptosis or programmed cell death in the neoplastic cells of breast cancer.
Madrid-based Complutense University went another avenue studying instead the synergistic qualities of cannabidiol in the enhancement of the cancer cell-killing effects of onco-chemotherapeutic agents.
The study underscored the activity of CBD in hastening the rate upon which the active ingredients of chemotherapeutic agents are absorbed by cancer cells.
At the same time the study observed healthy, normal cells were substantially protected because of their reduced exposure to the chemotherapeutic agents. Again, while these studies have been performed in test subjects other than dogs, the implications are nevertheless promising. Since certain breeds of dogs are also more prone in the development of certain types of cancer, adding CBD oil in their diet or even as regular supplementation should protect them against these cancers.
The benefits of CBD oil for dogs should be readily apparent. These can be gleaned both on how they work and the different health conditions upon which these supplements can be used. Generally, these benefits are as follows. Best Carpet Cleaner for Pets. The inhibitory effect of cannabidiol is one of the most sought-after properties of CBD oil for dogs. Reducing canine anxiety can translate to a variety of benefits for pet parents, too. It allows them the ability to train their dogs properly without causing hyper-excitability or extreme eagerness.
Many of the stress- and anxiety- related canine behavioral problems can also be addressed more efficiently. This means your dog will no longer be tearing apart your furniture, upholstery, bedding, carpet, and anything that it can get its jaws on every time it feels anxious.
You need not worry about going after urinary and fecal accidents anymore, saving you the hassle of messy cleanups while keeping the integrity of your belongings. More importantly, your dog will be calmer, more relaxed, and better equipped to handle frustrations, boredom, and other potential sources of canine anxiety. Best Dog Training Books. With CBD you can help minimize the ill effects of reduced oxygen supply to the brain by helping normalize the firing of nerve impulses from the brain.
Do take note that cannabidiol is not a treatment for seizures as this condition can have a variety of causes. This alone is a benefit that other supplements, let alone medications cannot provide. While it is true that cannabidiol can provide exceptional control of the growth of cancer cells, its cancer-fighting ability is limited only to those types of neoplastic conditions that have already been proven in laboratory settings. Unfortunately, the list is still short considering that there are hundreds of potential cancers that can hit any breed of dog.
Knowing that CBD oil can induce cell death in neoplastic cells while speeding up the rate of uptake of chemotherapeutic agents by cancer cells should provide hope for those pet parents who may have pooches that have certain types of cancers. It is not a cure for all cancers that are known to affect dogs.
But the mere fact that it can play a role in the more effective management of cancers is sure a welcome relief. Alleviating pain in your dog should help it with its mobility and enjoy its existence to the fullest. They will not be able to tone and strengthen their muscles. In short, their muscles will atrophy or shrink in size and lose their tone.
This can lead to other problems. A dog in pain will also not want to eat which robs it of invaluable nutrients necessary for continued development. It also robs your dog of the much-needed nutrients that can play a role in reducing pain sensation.
With CBD oil you can help your dog move as freely as possible by reducing, if not eliminating pain sensation. Inflammatory disorders are a very common occurrence in dogs.
From the gastrointestinal tract to the cardiovascular system to the skin and the respiratory system and a whole lot more, these conditions can also bring discomfort to your beloved pet. And since inflammation is almost always accompanied by pain or discomfort, addressing inflammatory conditions means improving the performance of daily activities of your dog.
If the inflammatory disorder happens to be limited to the GIT, then your dog will not be able to receive all the essential nutrients that it needs. If there is inflammation of the skin your dog will be exposed to secondary bacterial, fungal, or even viral infections because of breaks in the skin secondary to incessant scratching. If the inflammation occurs in the lungs or even in the cardiovascular system, then the issues will be related to oxygenation. Cannabidiol can help reduce inflammation and free your dog from all of these nuisances.
This is one of the most profound benefits of using CBD oil for dogs. As already explained, since cannabinoid type 2 receptors are also found abundantly in immune system peripheral tissues like the spleen, thymus, and tonsils as well as in cytokines that mediate the immune system response, one can expect greater immune system functionality in dogs receiving CBD oil.
In addition to the improvement in the overall immunologic activity of macrophages, B-lymphocytes, and neutrophils, CBD oil also exerts beneficial activity on T-lymphocytes especially immunoglobulin-M levels.
This type of immunoglobulin is an unusually large type of immune system cell that is the first to respond to antigenic exposure. This enhances the immunologic activity of the complement system which further aids in the management of antigen-antibody interactions.
What this simply means is that your dog will be more than ready to face any kind of infection that is sent its way. On hind sight, the improvement in immunologic marking can also play an important role in the identification of hyperplastic cells that have the tendency to mutate and become neoplastic cancer cells.
The neuroprotective capability of CBD oil is directly related to its inhibitory effects on nerve impulse transmission. The generation and propagation of electrical nerve impulses require energy. This can seriously deplete brain cells of glucose and oxygen necessary for other metabolic and physiologic processes. By limiting the firing or discharge of nerve impulses, CBD oil can make the brain and its related structures to go into preservation mode.
This helps relax the brain and its many neurons, allowing them to operate at a more normal pace. The nervous system is an integrative system. These drops are ultra-pure, taste like hemp, and are easy to use. Simply place the desired amount under the tongue, hold for seconds, swallow and you are are set. Check out the complete Endoca brand review here. These capsules are convenient potent and should last you 30 days.
Produced in Colorado, Sol CBD provides a cost effective solution for people who do not like the taste of tinctures or who do not want to be fussing with dosages.
Simply take the capsule, and go. Sol CBD capsules are grown from specially bred, organic, hemp without the use of any dangerous chemicals. CO2 extraction is used to ensure purity and quality. These vegetarian-friendly capsules contain a full spectrum of cannabinoids and include a full spectrum of terpenes, phytocannabinoids, and other important compounds that occur naturally in the cannabis plant.
These capsules are a convenient delivery method to get your CBD in the body without any taste at all. This starter pack has everything you need to find relief when you need it: And with a 1mg of CBD per inhale standard 10x that of a standard vape! For years Vape Bright has been committed to delivering a potent product with a terpene profile that puts competitors to shame.
Vape Bright has limited their focus to two different vape cartridges, the Thrive and the stronger Thrive Beyond, meaning that they are able to focus their efforts on research and development so that they will only ever provide the best product to consumers. Check out the complete Vape Bright brand review here. What sets CBDfx apart in our books is not only the fact that it comes in 6 different flavors but that they provide a full spectrum product with the certificate of analysis to back it up!
The available flavors include: Available in a mg, mg and mg size, you can be sure to get the dosage you both want and need. Keep in mind this is e-liquid and you will need an empty vape cartridge or vape mode to utilize this product.
Check out the complete CBDfx brand review here. Not only does it contain the right amount CBD oil for pain relief, the other ingredients, including shea butter, cocoa butter and coconut oil, will leave your skin feeling silky and smooth. As mentioned before, Endoca is dedicated to natural and sustainable processes so you can be sure that this product is of the highest quality.
When it comes to application, a little goes a long way. The exact amount required for relief is different for each person but it is pretty hard to go overboard so do not be afraid to experiment until you find the ideal amount for you.
With a CEO that has over 20 years experience working with medical cannabis, you can be sure you are getting a top shelf product. Mana Artisan Botanics has dedicated themselves to conscientious sourcing and producing a phytocannabinoid rich product that supports the endocannabinoid system. The Hawaiian Hemp Honey is made with a blend of Lehua and Wilelaiki honey, infused with small batch organic hemp extract. One ounce of honey delivers mg of hemp extract.
If you like sweet things, this honey is for you. Add a little to your coffee or tea, spread it on your toast at breakfast, or dip the spoon in the jar and put a dollop directly on your tongue. This is a truly delicious way to use CBD oil for pain relief. Check out the complete Mana Botanics brand review here. Based in Colorado, the family run Pure Spectrum is dedicated to providing the best CBD products to help you heal and live a long and happy life. Containing only anhydrous cannabidiol, you are getting all CBD oil for pain relief and nothing more.
Check out the complete Pure Spectrum brand review here. Not only is this good news for people following a plant-based diet, it is good news for people who want to avoid added ingredients like corn syrup and artificial sweeteners. Each gummy contains 5mg of pure CBD oil for pain management.
CBD Oil Review’s – Top 10 CBD Products to Buy
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