Pure and Organic CBD & and Hemp Products

Effective medicine provided by mother nature

  • Powerful relaxant

  • Strong painkiller

  • Stress reduction
  • Energy booster

Why CBD?

More and more renowned scientists worldwide publish their researches on the favorable impact of CBD on the human body. Not only does this natural compound deal with physical symptoms, but also it helps with emotional disorders. Distinctly positive results with no side effects make CBD products nothing but a phenomenal success.

This organic product helps cope with:

  • Tight muscles
  • Joint pain
  • Stress and anxiety
  • Depression
  • Sleep disorder

Range of Products

We have created a range of products so you can pick the most convenient ones depending on your needs and likes.

CBD Capsules Morning/Day/Night:

CBD Capsules

These capsules increase the energy level as you fight stress and sleep disorder. Only 1-2 capsules every day with your supplements will help you address fatigue and anxiety and improve your overall state of health.

Order Now

CBD Tincture

CBD Tincture

No more muscle tension, joints inflammation and backache with this easy-to-use dropper. Combined with coconut oil, CBD Tincture purifies the body and relieves pain. And the bottle is of such a convenient size that you can always take it with you.

Order Now

Pure CBD Freeze

Pure CBD Freeze

Even the most excruciating pain can be dealt with the help of this effective natural CBD-freeze. Once applied on the skin, this product will localize the pain without ever getting into the bloodstream.

Order Now

Pure CBD Lotion

Pure CBD Lotion

This lotion offers you multiple advantages. First, it moisturizes the skin to make elastic. And second, it takes care of the inflammation and pain. Coconut oil and Shia butter is extremely beneficial for the health and beauty of your skin.

Order Now

USA | What Is CBD Oil – and Should You Use It?

Epilepsy Oil 2. CBD Treats

aeluros
15.04.2019

Content:

  • Epilepsy Oil 2. CBD Treats
  • Cannabinoids in the Treatment of Epilepsy: Hard Evidence at Last?
  • The Conversation
  • Information about the use of cannabis oil for epilepsy to gain seizure 1 to Schedule 2 that will enable their investigation in clinical trials.”. "Compared to other drugs used to treat epilepsy, I think Epidiolex, which in CBD oil produced by small companies with no federal oversight. Only certain patients have access to the cannabis-based oil under . approved Epidiolex, a CBD oral solution to treat seizures associated with.

    Epilepsy Oil 2. CBD Treats

    The reason that the BPNA is only recommending CBD is that there is some evidence to show that this newly developed drug can be effective in reducing some type of seizures in Dravet and Lennox Gastaut syndromes.

    Three double blind randomised controlled trials of pure CBD in children and young people with these syndromes has shown a greater reduction in monthly seizures compared to placebos. There was also a greater reduction in drop seizures in people taking CBD compared to those on a placebo. Further open label studies have shown that it may also have an anti-epileptic effect in the epilepsies in general.

    While some studies have also suggested that THC may have an anti-epileptic effect, animal studies suggest it can also trigger seizures. There is no evidence from randomised controlled clinical trials for products with higher proportions of THC more than 0. Concerns have also been raised about the effect of THC on the developing brain in children and young people.

    Evidence suggests that chronic exposure to THC can affect brain development, structure and mental health. There is also no good scientific evidence to support suggestions that the addition of THC in combination with CBD increases the efficacy of cannabis-based medicinal products for children. We welcome the rescheduling of these products from Schedule 1 to Schedule 2 that will enable their investigation in clinical trials.

    The BPNA also recommends that where children are already taking other cannabis-based products that contain higher proportions of THC, they should be transitioned on to CBD until strong evidence for these products can be produced through clinical trials.

    The Government has no plans to legalise the use of cannabis for recreational purposes. Possession of cannabis is illegal. This includes cannabis for medical use unless it has been prescribed for you. Cannabis-based medicinal products can only be prescribed by a specialist.

    A GP cannot prescribe the medication but could refer you to a specialist. The specialist will discuss all other treatment options with you first before considering a cannabis-based product.

    A prescription for medicinal cannabis would only be given when all other treatment options have been tried or are considered unsuitable, and would only be given if the doctor considers it to be in your best interests. MHRA is working with individual companies to ensure that CBD-based products that make medicinal claims should be licensed and meet safety, quality and efficacy standards to protect public health.

    To date, the MHRA has licensed no other cannabis based medicinal products as medicines. Skip to main content. In this section What is epilepsy? A major weakness in the presentation of the trial results is the failure to report changes in plasma concentrations of concomitant AEDs and, most notably, clobazam and N-desmethylclobazam. Two well controlled double-blind trials in patients with Lennox-Gastaut syndrome have been completed, but results to date have only been reported in summary form.

    Treatment-related serious adverse events were reported in nine CBD patients and one placebo patient. Elevations in transaminases occurred mostly in patients on concomitant valproate therapy and all resolved. Duration of the trial was 14 weeks 2-week titration and week maintenance. Total seizures were also significantly reduced in both CBD groups compared with placebo. Some elevations in transaminases were seen. Published reports, however, provide no information on concomitant therapies, and most notably whether, and to what extent, the clinical improvement on CBD therapy could be related to elevation in serum concentrations of other medications, most notably clobazam and N-desmethylclobazam.

    The interest in cannabis preparations in the treatment of epilepsies, particularly drug refractory childhood epilepsies, has skyrocketed in recent years. Marijuana and other cannabis products with moderate to high THC content utilized primarily for recreational purposes are generally unsuitable for this indication, not only because evidence for an anti-seizure activity of THC is equivocal and risk of seizure aggravation cannot be excluded, but also because THC is associated with many undesired effects, including addiction liability, psychiatric disorders, cognitive and motor impairment — and, possibly, also cardiovascular toxicity.

    Compared with THC, CBD shows a better defined anticonvulsant profile in animal models considered to be predictive of efficacy against focal and generalized seizures. Moreover, CBD is largely devoid of adverse psychoactive effects, and is considered to lack the abuse liability associated with THC-containing products.

    Improvement in seizure control, often associated with additional benefits on sleep and behaviour, have been reported in a sizeable proportion of cases, 87 but interpretation of these data is made difficult by the uncontrolled nature of the observations.

    Additionally, as discussed in this article, there are concerns about the quality and variability of many of the products used, 98 particularly because cannabis treatment is often initiated spontaneously by patients or caregivers without adequate medical supervision.

    Evidence concerning the potential anti-seizure efficacy of cannabinoids reached a turning point in the last 12 months, with the completion of the first high-quality placebo-controlled trials of a purified oil-based liquid CBD preparation in patients with Dravet syndrome and Lennox-Gastaut syndrome.

    Therefore there is now for the first time class 1 evidence that CBD improves seizure control when added on to other AEDs in patients with two difficult-to-treat epileptic encephalopathies.

    Available data, however, do not allow to conclude that CBD per se has anti-seizure activity. At least for the trial published in full, 85 a majority of patients were receiving concomitant clobazam therapy, and it is unclear whether the reported seizure benefits, as well as adverse effects, were related to a direct action of CBD, or were mediated by a previously described 5-fold elevation in plasma N-desmethylclobazam levels.

    For the two studies in Lennox-Gastaut syndrome, the proportion of patients on concomitant clobazam therapy was not reported, but it is likely to have been significant because clobazam is a frequently used comedication in patients with this syndrome.

    Clarification of the independent effects of CBD would require re-assessment of trial data for the subgroup of patients not comedicated with clobazam, or the conduction of further studies after excluding such patients or, alternatively, adjusting blindly clobazam dosages to maintain unaltered concentration of N-desmethylclobazam.

    Additional well controlled studies are also desirable to determine the potential value of CBD in other seizure types and epilepsy syndromes, including refractory focal epilepsies.

    One of the reasons for the utilization of cannabis products to have become so popular among patients and their caregivers is that these products are generally regarded as causing fewer adverse effects compared with traditional AEDs, partly out of the misperception that remedies derived from natural products are unlikely to be harmful. Although these results are encouraging, further studies are required to evaluate the safety profile of CBD and other cannabis products in greater detail, particularly after long-term exposure and whenever these products are used in subpopulations potentially at risk.

    Elevations of liver enzymes have been frequently observed, especially in patients comedicated with valproate, and although they were generally reversible, close observation for signs suggestive of hepatic toxicity is advisable. Nabiximols, an oromucosal spray formulation containing approximately equal amounts of THC and CBD, has been commercially available in several countries for a number of years and has a relatively extensive safety record.

    Unlike THC, CBD is not associated with the development of tolerance after repeated administration in various seizure models, and there is no evidence of a withdrawal syndrome developing after CBD discontinuation.

    These are exciting times for research in cannabinoids. After almost four millennia of their documented medical use in the treatment of seizure disorders, we are very close to obtaining conclusive evidence of their efficacy in some severe epilepsy syndromes. The era of evidence-based prescription of a cannabis product is within our sight.

    National Center for Biotechnology Information , U. Journal List J Epilepsy Res v. Published online Dec Emilio Perucca 1, 2. Author information Article notes Copyright and License information Disclaimer. Received Jul 11; Accepted Sep This article has been cited by other articles in PMC. Abstract The interest in cannabis-based products for the treatment of refractory epilepsy has skyrocketed in recent years.

    Cannabis, Cannabidiol, Epilepsy, Seizures, Review. Introduction The history of human use of the Cannabis plant goes back to the dawn of mankind. Open in a separate window. Chemistry and mechanisms of action The genus Cannabis refers to a flowering plant of which there are three main species, Cannabis sativa , Cannabis indica and Cannabis ruderalis.

    Table 1 A list of targets and actions reported for CBD based on results of studies in different experimental models and systems 24 — Pharmacological profile in experimental models of seizures and epilepsy Among the many active principles found in the cannabis plant, THC is the most widely investigated for its many actions, including its psychoactive effects and risks associated with overdose and abuse.

    CBD In preclinical studies, CBD has been found to be active in a variety of seizures models, including seizures induced by maximal electro-shock 39 — 41 and by pentylentetrazole in rats and mice, 42 — 44 audiogenic seizures in rats 45 and seizures induced by 3-mercaptopropionic acid, bicuculline, picrotoxin, cocaine and isoniazid but not strychnine in mice.

    Clinical evidence of efficacy and safety: Well controlled randomized trials The recent flurry of research focused on the potential usefulness of cannabinoids in epilepsy has resulted in the completion of three well controlled randomized trials, all of which evaluated a liquid proprietary oral formulation of CBD.

    Table 2 Adverse events most commonly reported in the randomized double-bind placebo-controlled trial of CBD in comparison with placebo in patients with Dravet syndrome Double-blind trials in Lennox-Gastaut syndrome Two well controlled double-blind trials in patients with Lennox-Gastaut syndrome have been completed, but results to date have only been reported in summary form. Conclusions and future perspectives The interest in cannabis preparations in the treatment of epilepsies, particularly drug refractory childhood epilepsies, has skyrocketed in recent years.

    Marijuana and the Cannabinoids. Friedman D, Sirven JI. Historical perspective on the medical use of cannabis for epilepsy: Phytochemical and genetic analyses of ancient cannabis from Central Asia.

    On the preparations of the Indian hemp, or Gunjah: Cannabis indica their effects on the animal system in health, and their utility in the treatment of tetanus and other convulsive diseases. Epilepsy and other chronic convulsive disorders. ElSohly M, Gul W. Constituents of cannabis sativa. Oxford University Press; The pharmacological basis of cannabis therapy for epilepsy. J Pharmacol Exp Ther. Marijuana, endocannabinoids, and epilepsy: Mechoulam R, Parker LA.

    The endocannabinoid system and the brain. Therapeutic effects of cannabinoids in animal models of seizures, epilepsy, epileptogenesis, and epilepsy-related neuroprotection. Cannabinoids as hippocampal network administrators.

    Cannabis and endocannabinoid signaling in epilepsy. Weeding out bad waves: Cerebrospinal fluid levels of the endocannabinoid anandamide are reduced in patients with untreated newly diagnosed temporal lobe epilepsy. Downregulation of the CB1 cannabinoid receptor and related molecular elements of the endocannabinoid system in epileptic human hippocampus.

    Dynamic changes of CB1-receptor expression in hippocampi of epileptic mice and humans. In vivo activation of endocannabinoid system in temporal lobe epilepsy with hippocampal sclerosis.

    Medical marijuana in neurology. Detyniecki K, Hirsch L. Marijuana use in epilepsy: Curr Neurol Neurosci Rep. Friedman D, Devinsky O. Cannabinoids in the treatment of epilepsy. N Engl J Med. Molecular targets for cannabidiol and its synthetic analogues: Inhibition of an equilibrative nucleoside transporter by cannabidiol: Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro.

    Effects of cannabinoids and cannabinoid-enriched Cannabis extracts on TRP channels and endocannabinoid metabolic enzymes. Voltage-gated sodium NaV channel blockade by plant cannabinoids does not confer anticonvulsant effects per se.

    Molecular targets of cannabidiol in neurological disorders. Gaston TE, Friedman D. Pharmacology of cannabinoids in the treatment of epilepsy. Cannabidiol in medical marijuana: Cannabidiol mellows out resurgent sodium current. Progress report on new antiepileptic drugs: Neurological disorders in medical use of cannabis: Effects of cannabidiol on behavioral seizures caused by convulsant drugs or current in mice.

    Cannabidiol displays antiepileptiform and antiseizure properties in vitro and in vivo. Karler R, Turkanis SA. The cannabinoids as potential antiepileptics. Consroe P, Wolkin A. Cannabidiol--antiepileptic drug comparisons and interactions in experimentally induced seizures in rats. Cannabidiol, a Cannabis sativa constituent, inhibits cocaine-induced seizures in mice: Cannabidiol exerts anti-convulsant effects in animal models of temporal lobe and partial seizures.

    The influence of cannabidiol and delta 9-tetrahydrocannabinol on cobalt epilepsy in rats. Protective effects of cannabidiol against seizures and neuronal death in a rat model of mesial temporal lobe epilepsy.

    An electro-physiological analysis of the anticonvulsant action of cannabidiol on limbic seizures in conscious rats. Phytocannabinoids as novel therapeutic agents in CNS disorders. A critical review of the anti-psychotic effects of cannabidiol: Neural basis of anxiolytic effects of cannabidiol CBD in generalized social anxiety disorder: Walter L, Stella N. The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis.

    Neurological aspects of medical use of cannabidiol. Cannabidivarin is anticonvulsant in mouse and rat. Cannabidivarin-rich cannabis extracts are anticonvulsant in mouse and rat via a CB1 receptor-independent mechanism. Molecular pharmacology of phytocannabinoids.

    Prog Chem Org Nat Prod. Pharmacokinetics and pharmacodynamics of cannabinoids. The current status of artisanal cannabis for the treatment of epilepsy in the United States.

    Safety and pharmacokinetics of oral cannabidiol when administered concomitantly with intravenous fentanyl in humans. Single dose kinetics of cannabidiol in man. Eur J Clin Pharmacol. Identification of cytochrome P enzymes responsible for metabolism of cannabidiol by human liver microsomes. Exogenous cannabinoids as substrates, inhibitors, and inducers of human drug metabolizing enzymes: GW Pharma Ltd; [cited Jul 6]. Cannabidiol CBD in Dravet syndrome: Cannabidiol, a major phytocannabinoid, as a potent atypical inhibitor for CYP2D6.

    Cannabidiol is a potent inhibitor of the catalytic activity of cytochrome P 2C Cannabinoids and cytochrome P interactions. Neuropsychiatric and general interactions of natural and synthetic cannabinoids with drugs of abuse and medicines. The utility of cannabidiol in the treatment of refractory epilepsy. Drug-drug interaction between clobazam and cannabidiol in children with refractory epilepsy.

    Complex pharmacology of natural cannabinoids: Cannabidiol inhibits THC-elicited paranoid symptoms and hippocampal-dependent memory impairment. Does cannabidiol protect against adverse psychological effects of THC? Cannabidiol in patients with treatment-resistant epilepsy: Trial of cannabidiol for drug-resistant seizures in the Dravet syndrome.

    Cannabinoids in treatment-resistant epilepsy: Anticonvulsant nature of marihuana smoking. Complex partial seizure symptoms affected by marijuana abuse. A case report and review of the literature. Marijuana use in adults admitted to a Canadian epilepsy monitoring unit. Marijuana use and epilepsy: Marijuana use and the risk of new onset seizures.

    Trans Am Clin Climatol Assoc. Grand mal convulsions subsequent to marijuana use. Cannabis and other illicit drug use in epilepsy patients.

    The legal status of cannabis marijuana and cannabidiol CBD under U. Cannabinoid dose and label accuracy in edible medical cannabis products. Food and Drug Administration. Food and Drug Administration; [cited Jun 26]. The health effects of cannabis and cannabinoids: National Academy Press; Hausman-Kedem M, Kramer U.

    Efficacy of medical cannabis for treatment of refractory epilepsy in children and adolescents with emphasis on the Israeli experience. Isr Med Assoc J. Maa E, Figi P. The case for medical marijuana in epilepsy.

    Cannabinoids in the Treatment of Epilepsy: Hard Evidence at Last?

    'Cannabis oil could treat epilepsy' the Mail Online reports. The participants were randomly assigned to 2 weeks of treatment with. *The Agriculture and Nutrition Act of (H.R. 2) legalizes hemp and Epidiolex is a purified (> 98% oil-based) CBD extract from the cannabis plant. The FDA approved the use CBD, derived from marijuana, to treat two rare forms of severe epilepsy.

    The Conversation



    Comments

    Stimorol2008

    'Cannabis oil could treat epilepsy' the Mail Online reports. The participants were randomly assigned to 2 weeks of treatment with.

    akknaqviny

    *The Agriculture and Nutrition Act of (H.R. 2) legalizes hemp and Epidiolex is a purified (> 98% oil-based) CBD extract from the cannabis plant.

    Pavluxa14

    The FDA approved the use CBD, derived from marijuana, to treat two rare forms of severe epilepsy.

    xxxxakxxx

    2).7 Crude preparations of cannabis include dried leaves, stems and flower .. epilepsy received an oil-based liquid formulation of 99% pure CBD at an .. AEDs in patients with two difficult-to-treat epileptic encephalopathies.

    Ecsstassy

    The ECS consists of 2 main receptors, CB1 and CB2, which can interact with Nonetheless, it is fine to use CBD oil to treat epilepsy and seizures in dogs, too.

    Add Comment