Cannabinoids can treat an array of skin conditions, according to a research review recently published in the Journal of the American Academy. Cannabinoids may soothe certain skin diseases, say researchers containing cannabinoids may be effective against eczema, psoriasis, atopic for cannabinoids is in the treatment of itch," said the study's senior author Dellavalle said for those who have used other medications for itch and skin disease. Marijuana may be useful in treating symptoms related to skin diseases including eczema and psoriasis, according to research. health-related issues, researchers are focusing on the four other agents, or cannabinoids, found.
Diseases Skin and Study: Cannabinoids Eczema, Psoriasis, Other Soothe
Nonetheless, there is increasing evidence of the potential of cannabinoids for the treatment of inflammatory skin diseases, including psoriasis and atopic dermatitis and for the treatment of auto-immune diseases such as scleroderma, characterised by inflammation and fibrosis.
Psoriasis is one of the most common chronic inflammatory skin diseases. It is characterised by hyper-proliferation and shedding of keratinocytes, resulting from infiltration of T-cells and neutrophils and activation of dendritic cells and macrophages.
Although the pathogenesis of psoriasis is not fully understood, there is solid evidence to suggest that deregulation of the immune cells in the skin, in particular Th1 and Th17 cells, plays a critical role in the development of psoriasis. Although there is at present only anecdotal evidence on the use of Cannabis sativa L preparations for topical use in psoriasis, the therapeutic possibilities of cannabinoids acting through CB2R and through mechanisms that are independent of classical cannabinoid receptors are very broad given their role in the regulation of Th1 and Th17 lymphocytes Derakhshan and Kazemi, It has also been seen that some phytocannabinoids inhibit the proliferation of keratinocytes through non CB1R and CB2R paths Wilkinson and Williamson, Atopic dermatitis AD is the most frequent chronic inflammatory disease of the skin.
Initiation and progression of the disease are induced by interactions of genetic, environmental and immunological factors. The clinical characteristics of AD include dryness of the skin through loss of the epidermal barrier, erythema, exudation, scabs and lichenification. Moreover AD is characterised by intense itching which leads to frequent scratching and infection by staphylococcus.
There is no cure for AD and the main goals of treatment are to reduce the symptoms itching and dermatitis , prevent exacerbations and minimise the risk of skin infection.
Standard forms of treatment for managing AD patients centre on the use of anti-inflammatory topical preparations with corticoids and hydration of the skin, but in serious cases, patients may require systemic treatment with powerful immunosuppressives —such as cyclosporin A or tacrolimus— and antibiotics to prevent infection by staphylococcus-type bacteria. Numerous para-pharmaceutical preparations are now available based on oil from Cannabis sativa L seeds, especially hemp, for the treatment of AD.
However, despite the misleading advertising often used to market such products, hemp seed oil does not contain cannabinoids or other bioactive phenolic compounds, and its therapeutic effect goes no further than any other preparation containing polyunsaturated fatty acids and favouring skin hydration. However, to judge from pre-clinical studies, cannabinoids also have great potential for therapeutic management of AD Ong PY, ; Wollenberg and cols, In this regard, selective CB1R agonists inhibit the activation of mastocytes and the release of histamine.
Moreover, topical application of anandamide analogs has been shown to reduce skin inflammation in animal models of AD Kim et al. Other authors have suggested that CB1R expression in keratinocytes plays a relevant role in maintaining the epidermal barrier Gaffal et al. Finally it has also been described that the release of histamine from CB2R inhibits the inflammatory skin reaction mediated by IgE and intense spontaneous pruritus in AD Maekawa et al.
The antibacterial action of Cannabis sativa preparations and phytocannabinoids has been well known for decades, although only more recently has the antibacterial activity of cannabinoids THC, CBD, CBG and their precursors acid forms against methicillin-resistant staphylococcus been demonstrated Appendino et al. The cannabinoids and other types of compound are thought to have interacting synergic effects.
This would explain why in some in vitro studies, better results have been obtained with extracts from the plant than with pure isolated compounds. Although the content of cannabinoids and other types of compound varies depending on the variety of plant, cannabinoids can be said to have huge potential for treating AD, given their anti-inflammatory and antibacterial properties. Systemic scleroderma or sclerosis SSc is a rare autoimmune disease that has three main characteristics: SSc is characterised by progressive thickening and fibrosis of the skin, secondary to excessive accumulation of collagen, which can be limited to the skin localised —or limited— cutaneous SSc or extend to internal bodies diffuse SSc.
SSc begins with a microvascular injury and inflammation. This is followed by fibroblast activation, a key event in the development of fibrosis. Recent evidence shows that genetic and pharmacological manipulation of the endocannabinoid system modulates the fibrotic response. CB1 and CB2 receptors, too, have shown different patterns in experimental models of dermal fibrosis. Blockage of CB1R prevents activation of fibroblasts and has a powerful antifibrotic effect Marquart et al. The role of CB1R as a profibrotic receptor has also been confirmed in knock-out mice for FAAH, in which high levels of endocannabinoids can induce fibrosis through a CB1R-dependent path.
On the other hand, activation of CB2R prevents cutaneous fibrosis and the infiltration of tissue leukocytes in models of experimental dermal fibrosis Akhmetshina et al. This concurs with the fact that the CB2R knock-out mice are more susceptible to the development of fibrosis Balistreri et al.
The cannabinoid receptor CB2 exerts antifibrotic effects in experimental dermal fibrosis. Arthritis and rheumatism ; Antibacterial cannabinoids from Cannabis sativa: The cannabinoid WIN55, abrogates dermal fibrosis in scleroderma bleomycin model.
Annals of the rheumatic diseases ; Derakhshan N, Kazemi M. The cannabinoid quinol VCE Even if it does contain trace amounts of THC, cannabis infusions act on a peripheral basis and do not enter the bloodstream. Therefore, it can be safely used with zero psychoactive effects on your body or the risks of failing a drug test. Cannabis, when applied, topically, offer localized pain relief while reducing swelling making them ideal to help with bug bites, scratches, and other skin abrasions.
The application of CBD relaxes and soothes skin and can be used to treat rashes, dry skin, and more serious skin conditions like atopic dermatitis AD , which is the most common type of eczema. According to research from the National Eczema Association NEA , cannabinoids bind to receptors in the skin that could reduce the symptoms and appearance of AD.
A post shared by Ambary Gardens ambarygardens on Feb 13, at 6: Psoriasis is a skin disease that is characterized by itchy, painful red patches on the skin. Currently, there is no known cure for the condition. Cannabis, however, is proving to be a powerful treatment for psoriasis.
According to a study , the cannabinoids in cannabis was found to inhibit the buildup of dead skin cells — a direct cause of psoriasis. While more research is needed, anecdotal evidence suggests cannabis as a potential treatment for psoriasis.
Cannabis, when applied topically, is found to slow the skin aging process. A study revealed that the CBD found in cannabis is a more potent antioxidant than vitamin C or E, making it effective in the treatment of wrinkles and fine lines. In addition, they also neutralize free radicals and keep them from damaging the collagen and elastin in your skin, keeping your skin tight and youthful in appearance.
So not only does cannabis make your skin looking more youthful, it also keeps it healthier. Cannabis is loaded with essential fatty acids which provide hydration that is often found to be lacking in people with acne. Its antibacterial properties can help treat the bacterial infection on the skin which is a major contributor to acne. Moreover, another study showed that CBD cannabidiol inhibited and helped regulate lipid production, helping to combat excessively oily skin.
Another study showed that the cannabinoids in cannabis can improve the appearance of acne because they are natural anti-inflammatories and can help to reduce the inflammation of active acne. According to a study, cannabis contains antimicrobial and antibacterial properties that can help in fighting skin infections. Both THC and CBD , the most popular compounds in cannabis, were found to provide relief for numerous bacterial skin infections like boils, cellulitis, impetigo, and even folliculitis.
According to a study , cannabis fights against MRSA, a bacterium that causes difficult-to-treat infections since it does not respond to many antibiotics. MSRA or Methicillin-resistant Staphylococcus aureus causes infections in different parts of the body, causing a life-threatening infection.
MARIJUANA MAY HELP CURE ECZEMA, ACCORDING TO RESEARCHERS
A new study finds that cannabinoids may help help soothe eczema, psoriasis, dermatitis, and even skin cancer, among other diseases. If you suffer from skin diseases, you know relief can be a rare find. According to a recent study published in Pharmacognosy Reviews, which deals Cannabis sativus] is useful for treatment of eczema and host of other skin. Cannabis oil could help treat eczema and psoriasis, scientists say some sort of skin condition and, for many, finding a cure can be hard work. suffer with eczema or psoriasis, after new research shows cannabis to have a.