Cannabinoids can “modulate” the functioning of the immune system. It is now understood that cannabinoids such as THC and CBD interact with the body's endocannabinoid system to produce various effects. Likewise, an earlier study from found cannabis to raise the T-cell . Amnesia Haze · 6. However, the magnitude of the immune response to sRBC was . Splenocytes (5 × cells) were treated with CBD ( μM) for 30 min at. In order to improve quality of life and life expectancy, prevention of acute and administered CBD ( mg/day) is a safe and efficient way to improve the .. 6. Di Marzo V, Piscitelli F. The endocannabinoid system and its.
system. boosts immune 6. your CBD
They act as a regulating tool: However, the difference between "immune modulating" and "immune boosting" can be tricky to decipher. It is generally felt that someone with autoimmunity would not want to take anything which boosts the immune system, but this is a point of contention among practitioners.
According to Kevin Spelman, faculty member in Botanical Medicine at National University of Natural Medicine, the definition of immune modulatory is the biphasic effect of an herbal medicine. The category of immunomodulation rests on biphasic activity. If someone's immune response is overly vigilant, there would be a down regulation of immune response. If someone's immune response is 'deficient' there would be an increase of immune activity.
Cannabis is a unique biphasic botanical remedy that can bring the system back into balance in numerous regards. Based on current research, cannabis therapies may provide benefit for autoimmune disease in three basic ways: Cannabis medicine may also treat symptoms of specific autoimmune diseases like ALS, rheumatoid arthritis, ulcerative colitis and Crohn's, fibromyalgia, Huntington disease, multiple sclerosis, and others.
The plant may decrease chronic pain, inflammation, and spasms associated with some of these conditions. There have been few specific investigations on cannabinoid treatment for AI, due to federal prohibition on human clinical trials. However, extensive studies in test-tubes and in animals have reported the anti-inflammatory benefits of cannabinoids for specific AI conditions like multiple sclerosis and rheumatoid arthritis. Investigation has demonstrated that CB2 receptors regulate many complex pathways of the immune system.
Preclinical studies show that triggering CB2 receptors can suppress immune response, which can be beneficial for those suffering with AI. CB2 can also inhibit production of pro-inflammatory cytokines and enhance anti-inflammatory cytokines, which helps to restore a balanced state.
However, there are conflicting reports as research has shown that CB2 activation, under certain conditions, may aggravate inflammation. There has been some preclinical investigation focusing on the role of particular cannabinoids in AI disease models.
CBD has been found to modulate the immune system instead of suppressing it. Cannabidiol also slows down T-cell production and suppresses immune system memory, meaning that CBD could cut down on the likelihood of future autoimmune attacks.
CBD has also been found to increase the expression of genes that deal with oxidative stress, which may reduce cell damage from autoimmune attacks. As for THC, this cannabinoid is immunosuppressive only at very high doses. In low doses can be helpful as an analgesic and anti-inflammatory. Its ability to activate CB2 receptors may down regulate T cell function and decrease the harmful effects of immune cells.
The role of cannabis terpenes for autoimmunity deserve further investigation as well. The terpene beta-caryophyllene, found in certain strains of cannabis and black pepper, is known to decrease inflammation through its ability to stimulate the CB2 receptor. Myrcene, another terpene, also has antiinflammatory properties. Based on preclinical evidence, cannabinoids may help bring the system back into homeostasis, protect against damage from AI attacks within the body, slow down overactive T-cell production, and prevent the immune system from being triggered.
Inflammation is the root cause of many illnesses, and autoimmunity is no exception. If inflammation response is regulated, there will be less likelihood of an autoimmune attack.
More investigation is needed to examine the particular role of cannabinoids for autoimmune disorders. Cannabinoid therapy has the potential to assist those with autoimmune conditions by decreasing systemic inflammation, with little to no side effects.
Preclinical evidence has found that cannabinoids can attenuate autoimmune inflammatory response. In an animal model of multiple sclerosis, CBD decreased the gene transcription that promoted inflammation. Despite a scarcity of specific human based studies, patients with autoimmune disorders have been able to improve their situation by integrating cannabis medicine into their lifestyle.
Bonni Goldstein has seen a number of patients with lupus and rheumatoid arthritis wean off pharmaceuticals and control their symptoms with cannabis, dietary changes, exercise, and stress reduction. Goldstein gave the example of a young patient with ankylosing spondylitis.
Goldstein reported that after two months on cannabis the patient discontinued three of the pharmaceuticals, experienced a significant improvement in her pain symptoms, and was "able to participate in her life again". Trial and error is required to find what works best for an individual's unique situation. While autoimmunity may be a complex and challenging situation in need of deeper investigation, there are holistic approaches one can take to manage their condition.
Sublingual sprays or tinctures taken as liquid drops also take effect quickly and last longer than inhaled products. When pain is localized, topical products can be applied.
Topicals affect the cells near application and through several layers of tissue but do not cross the blood-brain barrier and are, therefore, not psychoactive.
The skin has the highest amount and concentration of CB2 receptors in the body. Considering all of the studies together, which number over forty for various types of pain , CBD and cannabis are shown to have a rating of likely probable efficacy. It is one of the best-substantiated medical uses of cannabinoids. Sativex, a cannabis plant—derived oromucosal spray containing equal proportions of THC and CBD, has been approved in a number of countries for use to treat specific types of pain.
Numerous randomized clinical trials have demonstrated the safety and efficacy of Sativex for treatment of central and peripheral neuropathic pain, rheumatoid arthritis, and cancer pain. A study showed that CBD and CBC stimulated descending pain-blocking pathways in the nervous system and caused analgesia by interacting with several target proteins involved in nociceptive control.
Sleep Disorders Insomnia, Sleep Apnea Cannabis and sleep have a complex relationship that is only beginning to be understood by science. In general, for most people, indica strains are more relaxing and effective for sleep disorders, whereas sativa strains are more stimulating and tend to keep people awake. Several studies conducted between and demonstrated the variable effect of different cannabinoids on sleep.
Another study found CBD to be wake-inducing for most subjects, though some reported better sleep a few hours after taking it.
However, a significant number of people find THC, even indica strains, will make the mind more active. For these people, CBD oil can benefit them and tends to work well, providing the relaxation and calm for the mental as well as the physical body.
For these people, CBD taken at nighttime as part of a bedtime regime produces a restful sleep, not the alertness produced in the daytime. This bidirectional effect of CBD is the result of balancing the endocannabinoid system. In relation to sleep apnea, a animal study observed the ability of THC to restore respiratory stability by modulating serotonin signaling and reducing spontaneous sleep-disordered breathing.
It is suggested that patients work with a health care practitioner experienced in recommending CBD or medicinal cannabis so that dosage and delivery methods can be developed and fine-tuned on an individual basis.
As mentioned previously, while CBD-dominant products help some people sleep, in others it promotes wakefulness. These tend to be high in myrcene and linalool, a terpene shared with lavender and known to be effective for relaxation.
Cannabis combinations with ratios of 1: THC can be used when patients want to reduce psychoactivity. Oral consumption is recommended as it usually lasts the whole night. The micro to standard dose is usually recommended to treat insomnia and sleep apnea. When relaxing indica strains are used with higher THC levels, a dose of 5—10 mg is usually sufficient. Other people find they need larger doses, such as 15—40 mg.
CBD taken as a tincture or edible will aid in a restful six to seven hours of sleep. This type of disorder varies widely from one patient to the next. Often, one needs to perform some experimental research and try strains of different CBD: For immediate medicinal effects, vaporizing or smoking work well.
This can be helpful for either initial sleep onset or for wakefulness in the middle of a rest period but only lasts one to three hours. The medication effect is immediate, whereas most ingested products take thirty to sixty minutes before taking effect faster on an empty stomach and last six to eight hours. Vaporizers that use a cartridge filled with the CO2 concentrate are convenient and highly effective, and these are available in various ratios of CBD to THC. Using this rubric, the use of cannabis-based products for treating insomnia has a rating of likely probable efficacy based on the four studies available at press time 3.
A study with the pharmaceutical 1: THC spray showed good results in helping patients with chronic pain sleep better. Four patients in a case series treated with CBD in had prompt and substantial reduction in the frequency of RBD-related events without side effects.
The Dana Forum on Brain Science Trends in Pharmacological Science 36, no. Ashton and Paul F. Van Den Eeden, G. Van Bockstaele New York: Springer, , — Ameritox, , www. Radulovacki, and David W. Leonard Leinow has three decades of experience growing and studying medical cannabis and brings a unique spiritual perspective to his work.
In , he formed Synergy Wellness, a not-for-profit medical cannabis collective in California. Synergy Wellness has over 3, members in its collective and is an artisan organization making hand-crafted organic and natural whole plant-based products.
They are specialists in CBD cannabidiol , the non-psychoactive portion of cannabis, and are pioneers in this aspect of the industry. Leinow is known for his proprietary blends of tinctures and medicine used for cancer and epilepsy patients.
Juliana Birnbaum is trained as a cultural anthropologist and skilled in four languages and has lived and worked in the U. She was the first graduate of the Cornerstone Doula School, one of the most rigorous natural birth programs in the U. She is engaged variously as writer, editor, teacher, midwife assistant and mother when not attempting new yoga poses or learning how to garden.
Free Enlightened Living Course: By calming inflammation, reducing anxiety and soothing chronic pain, CBD helps to promote relaxation and encourage deep sleep. How are we gearing up for flu season? Golden Dream CBD Tea was formulated especially with sleep in mind, to bring you sweet, golden dreams. Brothers Apothecary Wild Rosin Honey combines the natural antimicrobial, soothing properties of raw, ethically-harvested wildflower honey with CBD. Want an easy immunity boost?
Keep a bottle on hand for an extra kick of immunity all winter long. Your email address will not be published. Notify me of follow-up comments by email. Notify me of new posts by email.
CBD for Boosting Your Immune System Against Winter’s Viruses
When it comes to the effects of cannabis on your immune system, it's not that easy. Learn what scientists have found in their research on CBD. If you have been considering taking CBD for immune system health or an autoimmune as well to prevent diseases and boost overall immune health? CBD and the Immune System: Bridged by the Endocannabinoid System . size of oil containing CBD and THC, she also takes 6 apricot kernels daily. With CBD oil, there is no risk of intoxication (getting high) , so much larger thereby protecting the nervous and immune systems from everyday stress. Although this clearly increases the market for CBD products, it also.