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Oxandrolone - Wikipedia
Oxandrolone , sold under the brand names Oxandrin and Anavar among others, is an androgen and anabolic steroid AAS medication which is used to help promote weight gain in various situations, to help offset protein catabolism caused by long-term corticosteroid therapy, to support recovery from severe burns , to treat bone pain associated with osteoporosis , to aid in the development of girls with Turner syndrome , and for other indications.
Side effects of oxandrolone include symptoms of masculinization like acne , increased hair growth , voice changes , and increased sexual desire. Oxandrolone was first described in and was introduced for medical use in Oxandrolone has been researched and prescribed as a treatment for a wide variety of conditions. It is FDA-approved for treating bone pain associated with osteoporosis , aiding weight gain following surgery or physical trauma , during chronic infection , or in the context of unexplained weight loss , and counteracting the catabolic effect of long-term corticosteroid therapy.
Oxandrolone improves both short-term and long-term outcomes in people recovering from severe burns and is well-established as a safe treatment for this indication.
Medical research has established the effectiveness of oxandrolone in aiding the development of girls with Turner syndrome. Although oxandrolone has long been used to accelerate growth in children with idiopathic short stature, it is unlikely to increase adult height, and in some cases may even decrease it.
Oxandrolone has, therefore, largely been replaced by growth hormone for this use. Many bodybuilders and athletes use oxandrolone for its muscle-building effects. Like other AAS, oxandrolone may worsen hypercalcemia by increasing osteolytic bone resorption.
Women who are administered oxandrolone may experience virilization , irreversible development of masculine features such as voice deepening , hirsutism , menstruation abnormalities , male-pattern hair loss , and clitoral enlargement. Unlike some AAS, oxandrolone does not generally cause gynecomastia because it is not aromatized into estrogenic metabolites.
Oxandrolone greatly increases warfarin 's blood-thinning effect, sometimes dangerously so. Compared to testosterone and many other AAS, oxandrolone is less androgenic relative to its strength as an anabolic.
Oxandrolone was first made by Raphael Pappo and Christopher J. Jung while at Searle Laboratories now part of Pfizer. The researchers first described the drug in The original brand name of oxandrolone was Anavar, which was marketed in the United States and the Netherlands. Among those using oxandrolone for non-medical purposes, it is often referred to colloquially as "Var", a shortened form of the brand name Anavar.
Outside of the United States, the availability of oxandrolone is quite limited. Oxandrolone is sometimes used as a doping agent in sports. There are known cases of doping in sports with oxandrolone by professional athletes.
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