Secure Connection FailedAside from testosterone sale or intersubject influence bon. Differences in the preference for absorption in the different regions of the GI tract account for the non steroidal anti inflammatory drugs side effects pdf of these drugs to cause injury in those regions wherein they accumulate. Bacterial flora and food antigens may be particularly important in promoting injury in the lower intestinal tract, whereas in the sterile winstrol oral cycle of the normal stomach these may have less significance except in achlorhydric states. The multiple cellular actions of NSAIDs are reviewed and the consequences of inhibiting prostaglandin cyclo-oxygenase considered. These consequences are separate from the concept of prostaglandin deficiency previously suggested by others.
korean-war.info | Science, health and medical journals, full text articles and books.
Aside from environmental or intersubject influence e. Differences in the preference for absorption in the different regions of the GI tract account for the propensity of these drugs to cause injury in those regions wherein they accumulate. Bacterial flora and food antigens may be particularly important in promoting injury in the lower intestinal tract, whereas in the sterile environment of the normal stomach these may have less significance except in achlorhydric states.
The multiple cellular actions of NSAIDs are reviewed and the consequences of inhibiting prostaglandin cyclo-oxygenase considered. These consequences are separate from the concept of prostaglandin deficiency previously suggested by others. If you have the appropriate software installed, you can download article citation data to the citation manager of your choice.
Simply select your manager software from the list below and click on download. Skip to main content. View all publication partners. Download PDF Article information. Vol 16, Issue 2, Vol 16, Issue 2, pp. Permissions Request Permissions View permissions information for this article. Send me a copy Cancel. Allen A and Garner A Mucus and bicarbonate secretion in the stomach and their possible role in mucosal protection. Body temperature dependency of gastric regional blood flow, acid secretion and ulcer formation in restraint and water-immersion stressed rats.
Google Scholar , Crossref , Medline. Balint GA and Varro V Prostaglandins and the alimentary tract. University Park Press , Baltimore , pp. Effect of non-steroidal and anti-inflammatory drugs on the human small intestine. Stimulation and inhibition of prostacyclin formation in the gastric mucosa and ileum in vitro by anti-inflammatory agents. Prostaglandin synthetase inhibitors and the gut. Raven Press , New York , pp. Correlation between gastric irritancy and anti-inflammatory activity of non-steroidal anti-inflammatory drugs.
Non-steroidal anti-inflammatory drugs—-Correlation of anti-inflammatory activity and gastric irritancy with ability to inhibit prostaglandin synthetase. Leukotriene formation in the gastrointestinal tract and effects of anti-inflammatory drugs. MTP Press , Lancaster , pp. Google Scholar , Crossref. Release of leukotrienes by rat and human gastric mucosa and its pharmacological modification. Treatment of phenylbutazone ulcerogenicity using effervescent granules containing certain adjuvants.
Stimulation by BW c and inhibition by cysteamine of duodenal epithelial alkaline secretion suggest a role of endogenous prostaglandin in mucosal protection. Google Scholar , ISI. Concentrations of acidic anti-inflammatory drugs in gastric mucosa. Google Scholar , Medline. Calcium channel blockers protect against ethanol-and indomethacin-induced gastric lesions in rats.
Prostaglandins and the gastro-intestinal mucosa: Are they important in its function, disease or treatment? Hydrophobic lining to the lumen of the stomach.
Inatomi N and Maki Y Effect of prostaglandins on mucosal blood flow and aspirin-induced damage in the canine stomach. Direct and adaptive cytoprotection. Increased intestinal permeability in patients with rheumatoid arthritis: A side-effect of oral nonsteroidal anti-inflammatory drug therapy?
Indomethacin decreases basal gastric mucosal blood flow. The biological significance of inhibition of prostaglandin synthesis. Hans Huber , Berne , pp. Aspirin can inhibit mucosal cyclo-oxygenase without causing lesions in the rat. Enhancement by intracerebroventricular thyrotropin-releasing hormone of indomethacin-induced gastric lesions in the rat.
Prostaglandins and prostaglandin synthetase inhibitors in gastrointestinal function and disease. Acute gastric mucosal bleeding. Prevention of phenylbutazone ulcer in the rat by glucose: Role of a glycoprivic receptor system. Protective effects of prostaglandins against gastric mucosal damage: Current knowledge and proposed mechanisms.
Distribution of aspirin in rumen and corpus tissue of rat stomach during first four minutes after administration. Relationship between lesion production, absorption and distribution of 14C-labelled acetylsali-cylic acid. Interrelationships between membrane-bound ATP-dependent energy systems, gastric mucosal damage produced by NaOH, hypertonic NaCl, HCl, and alcohol, and prostacyclin-induced gastric cytoprotection in rats.
Plenum Press , New York , pp. Wiley , New York , pp. The comparative gastric ulcerogenic activities of non-steroidal anti-inflammatory drugs. Agents and Actions 7: Comparative studies of gastric ulcerogenesis by non-steroid anti-inflammatory drugs: The role of aspirin in gastric ulceration. Some factors involved in the development of gastric mucosal damage induced by aspirin in rats exposed to various stress conditions.
Prostaglandins and the development of gastric mucosal damage by anti-inflammatory drugs. Agents and Actions Suppl. Comparison of the gastric ulcerogenic activity of new non-steroid anti-inflammatory drugs in stressed rats. A comparison of the gastric ulcerogenic activity of benoxaprofen with other non-steroid anti-inflammatory drugs in rats and pigs.
An analysis of the gastro-intestinal side-effects of non-steroid anti-inflammatory drugs, with particular reference to comparative studies in man and laboratory species. Effects of anti-inflammatory drugs on mucus production: Mechanisms of intestinal mucosal damage by non-steroidal anti-inflammatory drugs.
The mechanisms of gastro-intestinal ulceration by non-steroidal anti-inflammatory drugs. Rainsford KD ed Anti-Inflammatory and Anti-Rheumatic Drugs, 3 vols. Effects of modulators of products of the 5-lipoxygenase pathway on the development of gastric mucosal lesions induced by nonsteroidal antiinflammatory drugs in mice.
Agents and Actions Gastric ulcerogenicity of non-steroid anti-inflammatory drugs in mice with mucosa sensitized by cholinomimetic treatment. Introduction and historical aspects of the side-effects of anti-inflammatory analgesic drugs.
Mechanisms of gastric contrasted with intestinal damage by non-steroidal anti-inflammatory drugs. Prevention of indomethacin-induced gastro-intestinal ulceration in rats by glucose-citrate formulations: Role of ATP in mucosal defences.
Animal models for the assay of gastrointestinal toxicity of anti-inflammatory drugs. Comparative effects of some non-steroidal anti-inflammatory drugs on the ultrastructural integrity and prostaglandin levels in the rat gastric mucosa: Relationship to drug uptake. Relationship between drug absorption, inhibition of cyclooxygenase and lipoxygenase pathways and the development of gastric mucosal damage by non-steroidal anti-inflammatory drugs in rats and pigs.
Bio-chemical gastroprotection from acute ulceration induced by aspirin and related drugs. Why are non-steroidal anti-inflammatory drugs so gastrotoxic, even when given orally on solubilized salt formulations or parenterally? Prostaglandins and the digestive system. The Prostaglandins, PW Ramwell ed. Macmillan, London , pp. A medicinal chemist's perspective of side-effects of anti-inflammatory analgesic drugs.
A profile of the gastrointestinal toxicity of aspirin, indomethacin, oxaprozin, phenylbutazone and fentiazic in arthritic and normal Lewis rats. Effects of nonsteroidal anti-inflammatory drugs on rat gastric mucosal phosphodiesterase activity.
Alterations in blood vessels during gastric injury and protection. Szabo S and Szelenyi I Effect of nicotine and alcohol pretreatment on the gastric mucosal damage by aspirin, phenylbutazone and reserpine in rats.
Prostaglandin E2 binding sites in porcine oxyntic mucosa: