17-beta hydroxysteroid dehydrogenase 3 deficiencyThis crucial role of 17 beta-HSD is performed by at least five 17 beta-HSD isoenzymes having individual cell-specific test prop nandrolone phenylpropionate, substrate specificity, regulation mechanisms, and reductive or oxidative catalytic activity. Both estrogenic and androgenic 17 beta-HSD activities were found in all 25 rhesus monkey and 15 human peripheral intracrine tissues examined. Type 1 17 beta-HSD is a protein of amino acids catalyzing the formation of 17 beta-estradiol from estrone. Dehydrogenasf x-ray structure was the first to be determined among mammalian steroidogenic enzymes. Initially crystallized with NAD, the crystal structure of type 1 17 beta-HSD has just dehydrogennase determined as a 17b hydroxysteroid dehydrogenase with 17 beta-estradiol, thereby 17b hydroxysteroid dehydrogenase the conformation of the substrate-binding site. Type 2 17 beta-HSD degrades 17 beta-estradiol into estrone and testosterone into androstenedione, and type 4 17 beta-HSD mainly degrades 17 beta-estradiol into estrone and androstene-3 beta, 17 beta-diol into dehydroepiandrosterone. Types 3 17b hydroxysteroid dehydrogenase 5 17 beta-HSD, on the other hand, catalyze the formation of testosterone from androstenedione in the testis and peripheral tissues, respectively.
beta hydroxysteroid dehydrogenase 3 deficiency - Genetics Home Reference
From Wikipedia, the free encyclopedia. The Journal of Biological Chemistry. A convenient purification and demonstration of multiple molecular forms". Brook's Clinical Pediatric Endocrinology. Retrieved 29 April Yen and Jaffe's Reproductive Endocrinology. Principles of Molecular Medicine. HSD17B2 has both anti-estrogenic and anti-androgenic functions. Williams Textbook of Endocrinology.
Adult and Pediatric E-Book. Seminars in Reproductive Medicine. American Journal of Human Genetics. Molecular Aspects of Medicine. Journal of Applied Genetics. Disorders of Sexual Development in Males: Hormones, Brain and Behavior.
European Journal of Medicinal Chemistry. Molecular and Cellular Endocrinology. Mevalonate kinase Phosphomevalonate kinase Pyrophosphomevalonate decarboxylase Isopentenyl-diphosphate delta isomerase. Farnesyl-diphosphate farnesyltransferase Squalene monooxygenase Lanosterol synthase. D-lactate dehydrogenase cytochrome D-lactate dehydrogenase cytochrome c Mannitol dehydrogenase cytochrome. Glucose oxidase L-gulonolactone oxidase Xanthine oxidase. Vitamin K epoxide reductase Vitamin-K-epoxide reductase warfarin-insensitive.
Breast cancer, prostate cancer, endometriosis, osteoporosis . Liver, heart, prostate, testis, lung, skeletal muscle, kidney, pancreas, thymus, ovary, intestine, placenta, brain, spleen, colon, lymphocytes.
DBP deficiency , Perrault syndrome , prostate cancer. Prostate, mammary gland, liver, kidney, lung, heart, small intestine, colon, uterus, testis, brain, skeletal muscle, adipose tissue. Ovary, corpus luteum, uterus, placenta, liver, breast, testis, brain, adrenal gland, small intestine, lung, thymus, prostate, adipose tissue, others. Prostate, placenta, kidney, brain, cerebellum, heart, lung, small intestine, ovary, testis, adrenal, stomach.
Liver, small intestine, colon, kidney, heart, brain, placenta, lung, ovary, testis, spleen, thymus, prostate, peripheral blood leukocytes. Liver, pancreas, intestine, kidney, adrenal gland, heart, lung, testis, ovary, placenta, sebaceous gland. Heart, skeletal muscle, liver, kidney, adrenal gland, testis, placenta, cerebellum, pancreas, stomach, small intestine, large intestine, trachea, lung, thyroid, esophagus, prostate, aorta, urinary bladder, spleen, skin, brain, ovary, breast, uterus, vagina.
Liver, bone marrow, lung, ovary, testis, kidney, skeletal muscle, brain, bladder, nasal epithelia. RDH11   . To lanosterol Farnesyl-diphosphate farnesyltransferase Squalene monooxygenase Lanosterol synthase. To pregnenolone Cholesterol side-chain cleavage.