Lichen Planus MedicationThe skin plays an essential role in protecting the body topical steroid creams for lichen planus maintaining our overall health. It weighs between 7. If you are already diagnosed with the autoimmune condition Lichen Planus, you are probably familiar with the fact that the proper, timely care for your skin is crucial for your overall well-being. The list below represents the most effective Over-the-counter treatment methods tpoical Lichen Planus based on customer reviews. This topical cream is specially formulated licnen relief of topical steroid creams for lichen planus of psoriasiseczemalichen planusseborrheic dermatitis and other conditions provoking skin swelling, itching, and foe. It has been 2 days — 48 hours — and every time I apply the cream I am impressed with the calming effect. According to the reports available, customers are very happy with Noble Define catabolic and anabolic enzymes, having that OTH products for such serious skin conditions usually have bad reviews.
List of Lichen Planus Medications (42 Compared) - korean-war.info
May 12, Author: A second choice would be systemic steroids for symptom control and possibly more rapid resolution. Many practitioners prefer intramuscular triamcinolone mg every weeks. Oral metronidazole has been shown to be an effective therapy for some patients.
In a randomized double-blinded study, sulfasalazine at up to 2. For lichen planus of the oral mucosa, topical steroids are usually tried first. Topical and systemic cyclosporin have been tried with some success [ 22 ] ; however, a randomized double-blind study indicated that topical cyclosporin was a less effective but much more costly regimen than clobetasol.
Other options include oral or topical retinoids. Even with these effective treatments, relapses are common. Close monitoring of lipid levels is suggested for patients with lichen planus who are treated with oral retinoid agents because a case control study found that the risk of dyslipidemia in these patients is increased fold. Patients with widespread lichen planus may respond to narrow-band or broadband UV-B therapy. Risks and benefits of this treatment should be considered.
Long-term risks include dose-related actinic degeneration, squamous cell carcinoma, and cataracts. A phototoxic reaction with erythema, pruritus, phytophotodermatitis, and friction blisters could occur. UV-A therapy combined with oral psoralen consists of oral psoralen 0. Precaution should be taken for persons with a history of skin cancers or hepatic insufficiency. Apremilast may be an effective treatment for lichen planus but double-blinded, controlled trials are lacking.
These agents have anti-inflammatory properties and cause profound and varied metabolic effects. In addition, these agents modify the body's immune response to diverse stimuli. Topical steroids may be as effective as systemic steroids. Class I or II steroids in ointment form reduce pruritus in cutaneous lichen planus, but they have not been proven to induce remission.
Prednisone may decrease inflammation by reversing increased capillary permeability and suppressing PMN activity. Use with extreme caution in children.
The pediatric dose is determined more by severity of the condition than by age or weight. Betamethasone is for inflammatory dermatosis responsive to steroids. It decreases inflammation by suppressing the migration of polymorphonuclear leukocytes and reversing capillary permeability.
Use with extreme caution in pediatric patients. Children have a larger skin surface area to body weight ratio and less developed, thinner skin, which may result in greater amounts of topical steroid being absorbed compared with adults.
Use nonfluorinated topical corticosteroids. Triamcinolone is for inflammatory dermatoses responsive to steroids. Local injections have been reported to be effective. Halobetasol is used for inflammatory dermatoses responsive to steroids.
Children have a larger ratio of skin surface area to body weight and less developed, thinner skin, which may result in greater amounts of topical steroid being absorbed compared with adults. Isotretinoin is an oral agent that treats serious dermatologic conditions. It is a synthetic cis isomer of the naturally occurring tretinoin trans- retinoic acid. Both agents are structurally related to vitamin A. Isotretinoin decreases sebaceous gland size and sebum production.
It may inhibit sebaceous gland differentiation and abnormal keratinization. Tretinoin may be effective for oral lichen planus but not for cutaneous disease. It inhibits microcomedo formation and eliminates existing lesions.
Tretinoin makes keratinocytes in sebaceous follicles less adherent and easier to remove. It is available as 0. Acitretin is a retinoic acid analog, like etretinate and isotretinoin. Etretinate is the main metabolite and has demonstrated clinical effects close to those seen with etretinate.
Its mechanism of action is unknown. Topical treatment with cyclosporine under occlusion has been efficacious for genital lesions and may be beneficial in hypertrophic lesions. Mouthwash or oil-based solutions have been effective for oral lichen planus but seem to be no better than corticosteroids. Systemic treatment has been used for severe resistant cutaneous disease, oral or ulcerative foot involvement, and lichen planopilaris of the scalp. The pediatric population may require higher or more frequent dosing because of accelerated clearance; use with extreme caution.
Oral metronidazole is an imidazole ring-based antibiotic that has been shown to be an effective therapy for some patients presenting with lichen planus. Its mechanism is unknown. Hepatitis c virus infections in oral lichen planus: Hepatitis C virus and lichen planus: A case-control study of patients.
J Am Acad Dermatol. The relationship between lichen planus and hepatitis C clarified. Skin manifestations of chronic hepatitis C virus infection in Cairo, Egypt. East Mediterr Health J. Treatments for Cutaneous Lichen Planus: A Systematic Review and Meta-Analysis.
Am J Clin Dermatol. A systematic review of treatments. Efficacy of oral metronidazole in treatment of cutaneous and mucosal lichen planus. Efficacy of sulfasalazine in the treatment of generalized lichen planus: J Eur Acad Dermatol Venereol.
Cardiovascular risk factors in patients with lichen planus. Ultraviolet-B treatment for cutaneous lichen planus: Liver abnormalities in patients with lichen planus. A retrospective case-control study. Lichen planus patients and stressful events. Murphy R, Edwards L. Lichen planus in children: Prevalence of vulval lichen planus in a cohort of women with oral lichen planus: Unexpectedly high frequency of genital involvement in women with clinical and histological features of oral lichen planus.
A Review and Analysis of 38 Cases. Treatment of lichen planus. An evidence-based medicine analysis of efficacy. Cyclosporine in the treatment of dermatologic disease: An open-label pilot study of apremilast for the treatment of moderate to severe lichen planus: Lichen planus and dyslipidemia: Alpha Omega Alpha Disclosure: Received salary from Medscape for employment. Serve d as a director, officer, partner, employee, advisor, consultant or trustee for: Sign Up It's Free! If you log out, you will be required to enter your username and password the next time you visit.
Share Email Print Feedback Close. Medication Summary The first-line treatments of cutaneous lichen planus are topical steroids, particularly class I or II ointments. Corticosteroids Class Summary These agents have anti-inflammatory properties and cause profound and varied metabolic effects. Retinoid-like Agents Class Summary These agents modulate cell proliferation. Immunosuppressants Class Summary These agents modulate the immune system. Lichen planus shows Wickham striae white, fine, reticular scales.