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Metandienone , also known as methandienone or methandrostenolone and sold under the brand name Dianabol among others, is an androgen and anabolic steroid AAS medication which is mostly no longer used. Side effects of metandienone include symptoms of masculinization like acne , increased hair growth , voice changes, and increased sexual desire , estrogenic effects like fluid retention and breast enlargement , and liver damage.
Metandienone is readily available without a prescription in certain countries such as Mexico , and is also manufactured in some Asian countries. Metandienone was formerly approved and marketed for the treatment of hypogonadism , but has since been discontinued and withdrawn in most countries, including in the United States. Metandienone is used for physique- and performance-enhancing purposes by competitive athletes , bodybuilders , and powerlifters.
Metandienone binds to and activates the androgen receptor AR in order to exert its effects. Metandienone has high oral bioavailability. Metandienone is subject to extensive hepatic biotransformation by a variety of enzymatic pathways. Methods for detection in urine specimens usually involve gas chromatography-mass spectrometry. Metandienone was first described in CIBA filed for a U. It was also prescribed off-label as a pharmaceutical performance enhancement to weight lifters and other athletes.
After the Kefauver Harris Amendment was passed in , the U. FDA began the DESI review process to ensure the safety and efficacy of drugs approved under the more lenient pre standards, including Dianabol. Metandienone was introduced and formerly sold primarily under the brand name Dianabol. There are many known cases of doping in sports with metandienone by professional athletes. From Wikipedia, the free encyclopedia. Lowinson and Ruiz's Substance Abuse: Concise Dictionary of Pharmacological Agents: The Dictionary of Drugs: Chemical Data, Structures and Bibliographies.
Journal of Sport History. Archived from the original PDF on Alan Aragon's Research Review. Unitied States Drug Enforcement Administration. Medical Toxicology of Drug Abuse: Synthesized Chemicals and Psychoactive Plants. British Journal of Pharmacology. Rapid Communications in Mass Spectrometry. Disposition of Toxic Drugs and Chemicals in Man 8th ed. Football's first steroids team? Current Opinion in Endocrinology, Diabetes and Obesity. Muscle, Smoke and Mirrors. United States Department of Justice.
Drug Abuse Handbook Second ed. Androstanolone stanolone, dihydrotestosterone, DHT Androstanolone esters Bolazine capronate Drostanolone propionate dromostanolone propionate Epitiostanol Mepitiostane Mesterolone Metenolone acetate methenolone acetate Metenolone enanthate methenolone enanthate Stenbolone acetate Nortestosterone derivatives: Bolandiol dipropionate Nandrolone esters e.
By mouth , intramuscular injection veterinary . Androgen ; Anabolic steroid. AR agonists Testosterone derivatives: