Are declining testosterone levels a major risk factor for ill-health in aging men?This decline in testosterone occurs gradually, testosterone aging and quality of life as early winstrol gains his mids, testostterone can result in an increased risk of life-threatening illnesses such as obesity, diabetes, and heart disease. Testosterone deficiency can also lead to a number of disturbing symptoms, including loss of stamina and lean muscle mass, reduced libido, anxiety, depression, and adn decline. Known as the andropause, these changes are the male equivalent of female menopause. The good news is that many symptoms testosterone aging and quality of life testosterone deficiency can be reversed by restoring youthful testosterone levels in a variety of ways. Millions of men are now using testosterone-building supplements and even testosterone itself for this reason. Testosterone is the primary male sex hormone that is vital for sustaining proper erectile function and libido. It is testosterobe critically involved in building muscle, burning fat, and supporting endothelial function, energy level, mood, immune function, and bone density.
Testosterone, aging and quality of life. - PubMed - NCBI
This decline in testosterone occurs gradually, starting as early as his mids, and can result in an increased risk of life-threatening illnesses such as obesity, diabetes, and heart disease.
Testosterone deficiency can also lead to a number of disturbing symptoms, including loss of stamina and lean muscle mass, reduced libido, anxiety, depression, and cognitive decline. Known as the andropause, these changes are the male equivalent of female menopause. The good news is that many symptoms of testosterone deficiency can be reversed by restoring youthful testosterone levels in a variety of ways. Millions of men are now using testosterone-building supplements and even testosterone itself for this reason.
Testosterone is the primary male sex hormone that is vital for sustaining proper erectile function and libido. It is also critically involved in building muscle, burning fat, and supporting endothelial function, energy level, mood, immune function, and bone density.
Millions of men in the United States suffer from the effects of low testosterone levels. This population of testosterone deficient men will only grow in the future, as the number of aging American men increases.
Low testosterone is associated with increased morbidity and mortality. A recent study found that men with lower testosterone levels were more likely to die from cardiovascular disease and all causes compared with men who had higher levels. The authors concluded that low testosterone may be a predictive marker for those at high risk of cardiovascular disease.
Why am I just hearing about this? The medical community has been slow to recognize the consequences of low testosterone levels in aging males and, in fact, wrongly believes that restoring youthful levels of testosterone is dangerous and unwarranted.
Back in the mids, some drug companies sold a synthetic and chemically altered testosterone called methyltestosterone. They pawned this chemical off as real testosterone, even though it does not naturally exist in the human body. After several years on the market, some men taking this particular chemical developed liver cancer.
Beginning in the late s, overambitious and unscrupulous professional athletes began taking illegal anabolic steroids to gain an unfair competitive edge. Unfortunately, this abuse has wrongly clouded the important health benefits of prescribing testosterone therapy to correct its decline associated with aging and other diseases. In response to the sports abuse issue, federal law has made testosterone a controlled substance just like narcotics and amphetamines.
Illegal-use penalties can be severe for any doctor who improperly prescribes anabolic steroids. There are hundreds of studies in the medical literature showing the health benefits and safety of testosterone therapy. Miner and Seftel published a review of the medical literature on testosterone since the Institute of Medicine Report. Clinical studies have shown that testosterone replacement therapy in hypogonadal men improves metabolic syndrome indicators and cardiovascular risk factors.
Maintaining testosterone concentrations in the normal range has been shown to contribute to bone health, lean muscle mass, and physical and sexual function, suggesting that testosterone replacement therapy may help to prevent frailty in older men. Based on current knowledge, testosterone replacement therapy is unlikely to pose major health risks in patients without prostate cancer and may offer substantial health benefits.
Many studies have shown an association between low testosterone levels and a higher prevalence of coronary artery disease and aortic atherosclerosis. Recent studies suggest that testosterone-replacement may improve the symptoms of coronary artery disease.
A placebo-controlled crossover study in men with ischemic heart disease and low testosterone levels reported that exercise time and the time to development of ischemic changes on a treadmill test were both increased with testosterone-replacement therapy.
These and other medical studies provide mounting evidence of the clinical benefits of testosterone-replacement therapy in men with coronary artery disease. Type 2 diabetes is reaching epidemic proportions in America today. Likewise, metabolic syndrome—a condition marked by insulin resistance that dramatically increases the risk of heart disease and diabetes—is becoming increasingly more prevalent.
Growing research suggests that low testosterone levels may be intimately linked with insulin resistance and its related conditions of metabolic syndrome and diabetes. Restoring testosterone to youthful ranges may confer a wide array of benefits to men affected by type 2 diabetes.
The reported benefits of testosterone administration in these men include improved glucose homeostasis balanced sugar levels , reduction in abdominal fat, and improved erectile function. Testosterone, the chief male hormone, is essential for libido and erectile function, and plays a crucial role in mood, energy, bone health, and body composition.
Diminishing testosterone levels have been linked with disorders such as depression, fatigue, obesity, and cognitive decline. Low testosterone levels increase the risk of coronary heart disease as well as all-cause and cardiac mortality.
Restoring testosterone to youthful levels offers men a wealth of health benefits, including benefits for heart health, body composition, mood, and memory. Bioidentical testosterone has not been found to have adverse effects on the healthy prostate gland—in fact, it may help improve prostate symptoms in men with low-normal testosterone levels.
Testosterone therapy is contraindicated in men with prostate cancer. Regular blood testing can help you and your physician decide if testosterone therapy is right for you. Optimizing testosterone levels requires a multi-pronged approach that includes optimal diet, proper nutrition, nutritional supplements, exercise, and bioidentical testosterone, if necessary.
Testosterone appears to affect fat cell metabolism and fat loss in several ways through:. When fat cells are exposed to testosterone in a test tube, the activity of lipoprotein lipase is dramatically reduced. Stimulating fat burning by increasing the number of certain receptors on the fat-cell membrane that release stored fat.
Increasing insulin sensitivity and improving lipid and insulin metabolism, while enhancing growth of muscle fibers and decreasing fat deposits. All of these effects benefit body composition by promoting lean body mass and reducing fat mass. In a landmark study out of Sweden in , researchers gave a group of overweight men supplemental testosterone for six weeks.
Waist and hip circumference also decreased in 9 of the 11 men. Furthermore, a recent review highlights numerous placebo-controlled trials that have demonstrated both significant increases in lean body mass and decreases in fat mass after varying courses of testosterone supplementation in older men.
A common misconception among physicians is that testosterone administration adversely affects the normal prostate. This idea is not supported by the medical literature. A study indicates that testosterone is actually beneficial for the prostate gland in the vast majority of cases. In this study, researchers looked at multiple parameters, including prostate volume, prostate-specific antigen PSA levels, and lower urinary tract symptoms in a group of men with low or low-normal testosterone levels.
These positive responders all showed improvement in almost every parameter measured: Treatment-related changes in prostate volume, serum PSA, voiding symptoms, and urinary flow were minor. On the question of whether testosterone therapy causes prostate cancer, the answer clearly appears to be no. Cancer-screening tests such as a PSA test are necessary before replacement therapy.
Testosterone-replacement therapy is contraindicated in men with known prostate cancer. The most efficient way for me or other doctors to prescribe the proper dose of low-cost individually compounded testosterone cream is for patients to bring their recent blood test results to my office during the initial visit.
The Male Blood Test Panel can be ordered by calling I encourage men over age 35 to have this comprehensive blood test and evaluation performed annually. Life Extension members who reside in the Southern Utah area are welcome to call my office at to schedule an appointment for a medical consultation.
Depression is a leading cause of disability worldwide. In a recent study of 3, older men in Australia, researchers found that those with depression had significantly lower testosterone concentrations than men without depression. In my own practice, I have seen both younger and older men with low testosterone levels and depression improve remarkably after testosterone supplementation.
Other studies have shown an improvement in depression scores with testosterone therapy in patients with depression who are unresponsive to conventional treatments. Testosterone supplementation clearly seems to be beneficial for proper male mental and verbal function. Several studies have shown that decreased serum testosterone levels appear to adversely affect verbal memory in healthy young men. Short-term testosterone administration exerts a beneficial effect on spatial and verbal memory and enhances cognitive function in healthy men.
Optimizing testosterone levels in men requires a multi-faceted approach that includes proper lifestyle, nutrition, nutritional supplements such as lignan and plant extracts , 32,33 dietary modifications, and exercise, as well as testosterone supplementation and other prescriptive approaches when indicated.
Initially, a medical history and physical examination should be performed, along with a blood-testing panel that includes not only testosterone levels, but also other important parameters such as fasting glucose, PSA, estradiol, and complete blood counts CBC.
It is important to work closely with a knowledgeable physician who is readily accessible and who can adjust treatment as needed. For men who no longer produce enough testosterone, an experienced doctor can prescribe a topically applied cream to restore testosterone to youthful ranges. These testosterone creams usually come in delivery systems that enable the precise amount of this hormone to be applied to the skin each day for absorption into the bloodstream.
The reason testosterone cream is used as opposed to tablets is that the oral ingestion of testosterone can result in rapid degradation in the liver and wildly inconsistent blood levels. A testosterone cream, on the other hand, gradually releases into the bloodstream, which is more analogous to the way testosterone is naturally secreted each day by the testicles of younger men.
For those patients in whom a cream is not the best choice, testosterone injections can be prescribed. Follow-up blood testing days later is important to ensure that PSA, estradiol, and other blood markers stay in normal ranges. If you have any questions on the scientific content of this article, please call a Life Extension Health Advisor at His integrative medical practice uses the most effective treatments from conventional medicine and natural medicine to restore health and vitality to patients with hormone- and age-related health decline.
Studies show that men using agents that lower dihydrotestosterone have reduced rates of both benign and malignant prostate disorders. Accessed April 24, Endogenous testosterone and mortality due to all causes, cardiovascular disease, and cancer in men: Risks of testosterone replacement therapy in ageing men. Expert Opin Drug Saf. The extent and nature of testosterone use [news release]. Int J Clin Pract. Testosterone and atherosclerosis in aging men: Am J Cardiovasc Drugs.
An assessment of correlations between endogenous sex hormone levels and the extensiveness of coronary heart disease and the ejection fraction of the left ventricle in males. Low levels of endogenous androgens increase the risk of atherosclerosis in elderly men: J Clin Endocrinol Metab. Testosterone replacement in hypogonadal men with angina improves ischaemic threshold and quality of life.
Effect of oral administration of testosterone on brachial arterial vasoreactivity in men with coronary artery disease. Metab Syndr Relat Disord. Testosterone, diabetes mellitus, and the metabolic syndrome.
Androgen deficiency, diabetes, and the metabolic syndrome in men.