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Pediatric Adrenal Diseases: Workshop, May , , Turin (Italy) - Google Books
In the GR-gene, three single nucleotide polymorphism SNPs have been associated with changes in metabolic profile and cardiovascular parameters: Importantly, the NS and the Bcl 1 are found to increase cortisol responses to a psychosocial stressor.
As a result, the whole body will suffer from overexposure with possible adverse effects on metabolism, cardiovascular control, immune function, and behavior.
Also in the MR gene, variants are being identified that are associated with dysregulated autonomic, behavioral, and neuroendocrine responses. The data suggest that these MR and GR variants contribute to individual differences in resilience and vulnerability to stressors, and that these receptors therefore are potential drug targets for recovery of homeostasis and health. Unable to display preview. Corticosteroid receptor genetic polymorphisms and stress responsivity.
This is a preview of subscription content, log in to check access. Mechanisms and biological significance of pulsatile hormone secretion. Novartis Foundation Symposium Science , — Nature , — Endocrinology , — Rivers, C, Levy, A. EMBO Reports 1 , — Steroids 61 , — Atherosclerosis , — BMJ , — Diabetes 51 , — Hypertension 41 , — Hypertension 34 , — Today 18 , — Steroids 67 , — Metabolism 49 , — Neuroendocrinology 62 , — Psychoneuroendocrinology 29 , 99— Psychoneuroendocrinology 30 , — USA , — Cite article How to cite?