Ecdysteroids – Protein Synthesis equal to Anabolic SteroidsThe amounts of ecdysteroids in bodybuilding supplements are probably sufficient ecdysteroids bodybuilding stimulate growth of muscle mass, write endocrinologists at the University of Goettingen, Germany, in an article in the Journal of Steroid Biochemistry and Molecular Ecdysteroids bodybuilding. In animal studies, modest doses of med tech solutions steroids for sale ecdysteroid hydroxy-ecdysone [structural formula shown below] increased the muscle mass of rats and also reduced the amount of body fat. Seidlova-Wuttke is a gynaecologist by training who bodyvuilding in the use of medicinal herbs. Her current research in Germany is ecdysteroids bodybuilding whether ecdysteroids are of use to post-menopausal women. She already publish the results of a study that showed that ecdysterone strengthens the bones and joints of female rats. The animals Seidlova-Wuttke uses for her experiments have had their ovaries removed, so they produce very low ecrysteroids ecdysteroids bodybuilding sex hormones. In the study that will be published bodybuioding in the Journal of Steroid Biochemistry and Molecular Biology, the researchers gave rats 18, 56 or mg ecdysterone orally every day.
Low doses of ecdysteroids promote muscle building | IronMag Bodybuilding Blog
Ecdysteroids are a class of hormones that are the androgens of insects; they are involved with reproduction and molting, but human ingestion might be healthy or increase muscle mass. Human interventions are lacking and problems with ecdysteroid ingestion exist. This page features 66 unique references to scientific papers. Ecdysteroids are a class of compounds polyhydroxylated ketosteroids, with various tails that are structurally similar to androgens. They are well studied as plant and insect growth factors, and derived their name ecdy- from the process of molting in insects, called ecdysis.
Ecdysteroid is a category, and popular ecdysteroids include 'ecdysone', 'ecdysterone', 'turkesterone' and 'hydroxyecdysone'. These four are the most commonly studied, but each ecdysteroid shares the same general properties although varies in potency and effects slightly.
Turkesterone appears to be the most anabolic. They have some biological effects in mammals when orally ingested, and have been called by some researchers as "behaving similar to anabolic steroids putatively without the androgenic effect".
Additionally, they seem to have a wide variety of side-effects that are deemed as healthy. Ecdysteroids can lower cholesterol and blood glucose, are seen as healthy for the liver and intestines by increasing protein synthesis rates, and may have protective effects on neural tissue. A lack of trails are currently available for humans, but promising evidence is available for in vitro studies on human muscle fibers as well as a multitude of animal models showing enhanced growth rates with ecdysteroid ingestion.
Suma extract, pfaffia extract, Brazilian ginseng extract, beta-ecdysterone, turkesterone, ecdysterone. Hypoglycemic effects of edcdysterone and its plant sources seems to be dose-dependent, although a good dose that is used safely is typically mg a day.
So, humans have an EcR receptor for insect hormones? Not perfect as we lack the USP receptor which logic should dictate, since we aren't insects but apparently this may be one of the possible reasons as to why insect hormones actually do work in humans, aside from the cytoplasmic receptor. There may be an entire ecdysterone signalling system, which is interesting.
I cannot say much about the effects of ecdysteroid supplementation, but it is a very interesting topic. At least one study says that a certain ecdysteroid turkesterone is as potent as an anabolic-androgenic steroid Nerobol and animal models do consistently show increased weight.
But it doesn't increase testosterone at all. This is either a blessing or a curse; it increases protein synthesis, so isn't that good enough? The Human Effect Matrix looks at human studies it excludes animal and in vitro studies to tell you what effects ecdysteroids has on your body, and how strong these effects are.
Some plants that are higher in certain bioactive ecdysteroids are:. Spinacia oleracea Spinach, source of hydroxyecdysone . Ajuga Turkestanica , a source of the C hydroxylated 'Turkesterone' . Vitex Scabra , having 1. Ecdysterones get their name from having a steroid backbone sterone and being associated with the process of molting, otherwise known as ecdysis.
The reason for their existence in plants as they are an insect hormone is that they protect plants from unadapted insects, and thus are a phytoalexin. Ecdysteroids share structural similarity to testosterone and are seen as the testosterone-like compound most active in insects. They are also present in plants to deter predators. Although there are over ecdysteroids known at the time of ,  and up to registered.
In one study, using 0. However, mouse models show a half-life of 8. A cytoplasmic receptor has been cloned in drosophilia, and termed DopEcR, which binds to ecdysterones and dopamine.
There are hypothesized nuclear receptors as well in mammals in the nuclear receptor superfamily . RXR must form in mammals for effects to occur. RXR; this was mentioned in one study  in regards to another investigating an in vitro model on Chinese Hamster Ovary cell line.
Ecdysteroids, specifically hydroxyecdysone and pinnatasterone, have been implicated as inhibitors of P-glycoprotein efflux pumps and may interact with other drugs that are metabolized extensively by P-glycoprotein, such as Berberine or Icariin. In mice and humans excretion is done both fecally and via the urine. When investigating the fecal metabolites, 4-deoxyecdysone was noted as well as compounds with a fully reduced B-ring.
In humans, urinary excretion of ecdysterone tends to be one of three compounds; either the ecdysterone in an unchanged form, 2-deoxyecdysterone or as deoxyecdysone.
The primary urinary metabolite, at Ecdysterone is able to increase enzymatic induction of both acetylcholinesterase  and glutamic decarboxylase. It also exerts some protective effects against neurological toxins.
Phytoecdysones the overarching family of which ecdysterone belongs to shows some promise as being cholesterol lowering agents  , probably through increased conversion of cholesterol into bile acids. These effects were found at 2. Ecdysterone interchangeable term with hydroxyecdysterone, or HE seems to be able to suppress hepatic glucose formation and thus lower blood sugar levels independent of insulin secretion and serum levels.
In vitro studies on muscle cells with hydroxyecdysone and turkesterone have noted statistically significant improvements in protein synthesis in a dose dependent manner starting at 0.
In direct comparative studies, the ecdysteroid called 'Turkesterone' appears to be more potent relative to other ecdysteroids studied   followed by cyasterone and then hydroxysterone. This study used Methylandrostenediol This calcium influx increases Akt phosphorylation more than 3-fold at a 0. In vivo studies have noted increased anabolism in a wide variety of animals, such as rats and mice,    pigs  and quail.
In sheep, an oral dose of 0. A similarily small dose of 0. The increased activity of Alkaline Phosphatase induced by Ecdysterone seems to be through the estrogen receptor. The increased activity seen in Type I collagen expression, osteocalcin, and Runx2 do not seem to be via the estrogen receptor. At the moment, only one human study has been conducted with ecdysterone. Dosed at mg daily, no results were seen in resistance training males in regards to total and free testosterone or body composition changes when compared to placebo.
That being said, despite no influence on testosterone itself ecdysterone may be able to exert testosterone-like effects via signal transduction pathways although the exact mechanism is not yet known ; an action with ultimately the same biological significance as testosterone. There is not much evidence beyond in vitro to suggest ecdysterone useful for muscle protein synthesis or strength gains. Ecdysterone also exerts protective effects against lipid peroxidation from free radicals, getting a status of anti-oxidant.
As discussed in the fat metabolism section, ecdysterone is able to increase bile secretion rates as well as improve liver regeneration after toxin heliotrine damage. In regards to skin, ecdysterone seems to be able to promote keratinocyte differentiation and accelerate small wounds and burns when externally applied.
Ecdysteroids are one of the pair of insect hormones the other being Juvenile Hormone that seem to be involved in insect lifespan, with ecdysterone being the agent that increases lifespan. Ecdysteroids, in total, are quite safe for ingestion.
Common misspellings for Ecdysteroids include ekdysterone, ecdisterone, ekdisterone, ecdysteron, ekdysteron, ekdisteron, sum. Please click here if you are not redirected within a few seconds. Ecdysteroids Ecdysteroids are a class of hormones that are the androgens of insects; they are involved with reproduction and molting, but human ingestion might be healthy or increase muscle mass.
History Research analysis by Kamal Patel and verified by the Examine. Last updated on Apr 29, Free 5 day supplement course. Also Known As Suma extract, pfaffia extract, Brazilian ginseng extract, beta-ecdysterone, turkesterone, ecdysterone Things to Note Ecdysterone is non-stimulatory. Grade Level of Evidence Robust research conducted with repeated double-blind clinical trials Multiple studies where at least two are double-blind and placebo controlled Single double-blind study or multiple cohort studies Uncontrolled or observational studies only.
The amount of high quality evidence. The more evidence, the more we can trust the results. The direction and size of the supplement's impact on each outcome.
Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Scientific research does not always agree. No differences between ecdysteroids and placebo in improving lean mass accrual during a weight lifting program. No difference between improvements in power output between ecdysteroids and placebo. No alterations noted in serum testosterone associated with ecdysterone consumption. In resistance trained males, no significant influence of ecdysterone supplementation on cholesterol. Link to This Close. Multiple studies where at least two are double-blind and placebo controlled.
Single double-blind study or multiple cohort studies. Uncontrolled or observational studies only. No demonstrated changes in cortisol levels with ecdysterone consumption.