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Which drugs dry you out? Lube your Joints ? GRow your tendons ?
There are currently 1 users browsing this thread. The thinner the better for me. I use 25g B-D Precision Glides. Results 1 to 21 of Which drugs dry you out? I'm having a hard time locating that one post made awhile back.. Join Date May Posts 2, Since collagen makes up tendons, bros are very prone to injury if they continue to lift very heavy, unless they cycle off T and let their collagen synthesis get back to normal.
It's like having the skeletal muscle of a gorilla with the tendons of a very old man. Winstrol increases collagen synthesis. It will give you bigger tendons. However, your body compensates for this by making them more brittle, weaker, and more prone to injury. I can't tell you how many bros work out anaerobically and become injured while on winstrol.
Guys who lift in the rep range while on winstrol, to baseball players who sprint all out from a stationary position -- winstrol should be the LAST drug they choose. Most of them like winstrol because they don't get the weight gain from it but it is very detrimental to bros who train for any sport anaerobically. Tendons tear easily on it. Also, the drugs I mention increase collagen syn while also increasing collagen cross-linking integrity, making for a much stronger tendon.
Winstrol, on the other hand, will dramatically increase collagen syn, but ironically it decreases collagen cross-linking integrity, thus making a much weaker tendon. You can plan a cycle of AAS which will increase collagen synthesis and skeletal muscle growth at the same time. The key is the drug s you choose. Deca , Equipoise , Anavar , and Primobolan will ALL increase skeletal muscle while at the same time dramatically increase collagen syn and bone mass and density, leaving you with a substantially reduced chance of becoming injured than if you choose to use AAS like sus, cyp, or enth.
While testosterone will increase bone mass and density, even at supra-physiological levels, the result is weaker tendons due to inhibition of collagen syn. Test at this dose will not inhibit collagen syn, but paradoxically, will help increase it.
Procollagen III is a primary indicator used to determine the rate of collagen syn. As you can see, deca is a very good drug at giving you everything you want -- an increase in collagen syn, an increase in skeletal muscle, and increases in bone mass and density. Oxandrolone has over a hundred studies documenting its effectiveness at treating patients needing rapid increases in collagen syn to enhance healing.
These drugs have longer half-lives than most other AAS, so this should be considered when timing your post cycle clomid use. GH is probably the most remarkable drug at increasing collagen synthesis. It increases collagen syn in a dose dependant manner -- the more you use, the more you will increase collagen syn. It has also demonstrated this ability in short and long term studies.
This result indicates that the increased biomechanical strength of wounds to collagen structures treated with biosynthetic human growth hormone was produced by an increased deposition of collagen in the collagen structures.
Eq, primo, anavar, and deca are all good -- they increase several biomakers of collagen syn -- ie, type III, II, I, procollagen markers.
GH just seems to do so most dramatically. Use of any of these drugs supra-physiological levels with a maintenance dose of test will increase collagen syn while at the same time increase skeletal muscle mass. Also, these drugs do not satisfy the libido like testosterone, but that is not the point of this thread.
It is only to demonstrate that you can increase skeletal muscle and collagen syn at the same time with certain AAS -- the decision is up to you Stimulation of collagen synthesis by the anabolic steroid stanozolol. J Invest Dermatol Dec; 6: In this report, we measured the effect of the anabolic steroid stanozolol on cell replication and collagen synthesis in cultures of adult human dermal fibroblasts. There was no stimulation of collagen synthesis by testosterone.
The stimulatory effects of stanozolol on collagen synthesis were blocked by a TGF-beta1 anti-sense oligonucleotide, by antibodies to TGF-beta, and in dermal fibroblast cultures derived from TGF-beta-1 knockout mice. We conclude that collagen synthesis is increased by the anabolic steroid stanozolol and that, for the most part, this effect is due to TGF-beta These findings point to a novel mechanism of action of anabolic steroids.
End of the study, the rest is just some dudes opinion from Meso-RX Discussion: I must first acknowledge that the commonly held belief is that anabolic steroids predispose an athlete to tendon rupture.
This conclusion is drawn from animal studies showing that some steroids produce a larger, stiffer tendon in rats and that these steroid-induced tendons "fail" before the tendons from the control animals.
The term fail refers to the breaking point. The interesting thing about the present study is that the steroid stanozolol Winstrol had a different effect than testosterone. If you are a regular reader of Meso-Rx you should be well aware that not all steroids act in the same manner. And that because of subtle differences in there molecular structure they are able to elicit different responses.
For example, Deca seems to act primarily through the androgen receptor AR where as Dianabol has effects beyond those associated with the AR. Because synthetic steroids have differ in their chemical properties it should not be surprising that testosterone did not have the same effect as Winstrol.
Winstrol increased collagen synthesis as opposed to testosterone which did not in this study. Interpreting the results of this study are more difficult than simply describing them. Other researchers have suggested that steroids cause a rapid increase in protein synthesis within tendon fibroblasts which results in fibroids or fibrous nodules within the tendon Michna, These fibroids alter the mechanical properties of the tendon perhaps predisposing it to rupture.
It is also noted that during short term use of steroids there is an alteration in the alignment of collagen fibers which may also lead to rupture. Interestingly these alterations in collagen metabolism are transient with markers of collagen turnover returning more or less to baseline after weeks of steroid administration Karpakka, These same researchers noted that low dose anabolics effect primarily muscle collagenous tissue with tendon being effected only at higher doses i.
The question remains, dose this mean that Winstrol will actually help prevent tendon injury or will it lead to bigger yet stiffer tendons prone to injury? It is difficult to take animal research and extrapolate the results to humans. Stanozolol is used therapeutically in humans to treat a variety of connective tissue and vascular disorders and its clinical effects suggest that it can modulate connective tissue breakdown in people. Despite being labeled as "ineffective" by many bodybuilders it is very popular among athletes.
As with most hormones, dosage plays a role in what effects are seen, be they positive or negative. Hopefully future studies will shed light on the therapeutic effects of different steroids on tendons in humans. Michna H Appearance and ultrastructure of intranuclear crystalloids in tendon fibroblasts induced by an anabolic steroid hormone in the mouse.
Acta Anat Basel ; 3: The effects of anabolic steroids on collagen synthesis in rat skeletal muscle and tendon. That's what I was looking for.. Nice posts Anhydro, but arent those studies alittle old?? I see the 1st reference was back in so thats like 16 years ago. Things have changed by now I would assume Here is a link with lengthy articles on the subject. Originally Posted by Ammar. Stanzolol helps but doesnt provide cross linking integrity and flexability.
Da bull They are posted on Steroid World. Ammar Where is the studies you know of going on right now. They could really care less how our steroid use effects our bodys. Ussually we have to look at studies done with aid patients and such. There just isnt anyone funding projects that study how 3,mgs a week of testosterone works in a trained athlete.
Alot of our speculations are derived from studys that really are not topic specific. Originally Posted by Anhydro Urbandawg I think your cycle looks great.
You have all the good collagen synthesis stimulating hormones to balance out the negative effect of testosterone. If you notice the Equipoise has better ratios than Deca , if you do increase your deca dose I personally wouldnt lower the Test level. Thats just my opinion. Anhydro, I was not arguing you with you at all bro. I was just curious if there were any newer studies about the subject. The one fear i have with that is since it's only my second cycle i odn;t think i need a ton of compounds yet, and don;t want to have to use more and more in my AS future OK Ill just stick with it.
Da Bull helped me cook that cycle thanks. If you notice the Equipoise has better ratios than Deca, if you do increase your deca dose I personally wouldnt lower the Test level. Join Date Feb Posts 8, Winstrol destroyed my joints. I had to quit using it. Deca definitely helped lube my joints.
Always always use Glucosomine while on Winstrol. Originally Posted by buylongterm. Originally Posted by UrbanDawg.